Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEJ61489.1PFAM: Flavin reductase like domain; COGs: COG1853 Conserved protein/domain typically associated with flavoprotein oxygenase DIM6/NTAB family; InterPro IPR002563; KEGG: sta:STHERM_c11810 hypothetical protein; PFAM: Flavin reductase-like, FMN-binding; SPTR: Flavin reductase domain protein FMN-binding. (172 aa)    
Predicted Functional Partners:
AEJ61488.1
PFAM: Aldo/keto reductase family; COGs: COG0667 oxidoreductase (related to aryl-alcohol dehydrogenase); InterPro IPR001395; KEGG: sta:STHERM_c11760 aldo/keto reductase; PFAM: Aldo/keto reductase; SPTR: Aldo/keto reductase.
       0.611
ribBA
GTP cyclohydrolase-2; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
  
  
 0.567
AEJ60727.1
PFAM: Fe2+ transport protein; COGs: COG3470 Uncharacterized protein probably involved in high-affinity Fe2+ transport; InterPro IPR018470; KEGG: sta:STHERM_c18170 hypothetical protein; PFAM: Ferrous iron transport protein, bacterial; SPTR: Ferrous iron transport protein.
  
     0.501
AEJ61487.1
PFAM: Bacterial regulatory helix-turn-helix proteins, AraC family; AraC-type transcriptional regulator N-terminus; COGs: COG2207 AraC-type DNA-binding domain-containing protein; InterPro IPR009594:IPR000005:IPR018060; KEGG: sta:STHERM_c11750 transcriptional regulator, AraC family; PFAM: AraC-type transcriptional regulator, N-terminal; Helix-turn-helix, AraC type; SMART: Helix-turn-helix, AraC domain; SPTR: Transcriptional regulator, AraC family.
       0.404
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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