Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEJ61501.1PFAM: Exonuclease; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family; COGs: COG2176 DNA polymerase III alpha subunit (gram-positive type); InterPro IPR006055:IPR013520:IPR006054; KEGG: sta:STHERM_c11930 hypothetical protein; PFAM: Exonuclease, RNase T/DNA polymerase III; SMART: Exonuclease; SPTR: DNA polymerase III, epsilon subunit; TIGRFAM: DNA polymerase III, epsilon subunit. (198 aa)    
Predicted Functional Partners:
AEJ60289.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
     
 0.925
AEJ61625.1
PFAM: Bacterial DNA polymerase III alpha subunit; PHP domain; OB-fold nucleic acid binding domain; TIGRFAM: DNA-directed DNA polymerase III (polc); COGs: COG0587 DNA polymerase III alpha subunit; InterProIPR003141:IPR004013:IPR011708:IPR004365:IPR 004805; KEGG: sta:STHERM_c08090 DNA polymerase III subunit alpha; PFAM: Bacterial DNA polymerase III, alpha subunit; PHP, C-terminal; Nucleic acid binding, OB-fold, tRNA/helicase-type; SMART: Polymerase/histidinol phosphatase, N-terminal; SPTR: DNA polymerase III, alpha subunit; TIGRFAM: DNA polymerase III, alpha subunit.
    
 0.924
AEJ62503.1
PFAM: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit; COGs: COG1466 DNA polymerase III delta subunit; InterPro IPR005790:IPR010372; KEGG: sta:STHERM_c22020 hypothetical protein; PFAM: DNA polymerase III, delta; SPTR: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit.
    
 0.921
AEJ60844.1
COGs: COG2812 DNA polymerase III gamma/tau subunits; KEGG: sta:STHERM_c05420 DNA polymerase III domain-containing protein; SPTR: Putative uncharacterized protein.
  
 
 0.912
dnaX
DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
  
 
 0.912
AEJ60849.1
Helicase c2; PFAM: Protein of unknown function (DUF2466); DEAD/DEAH box helicase; TIGRFAM: DnaQ family exonuclease/DinG family helicase, putative; COGs: COG1199 Rad3-related DNA helicase; InterPro IPR006555; KEGG: sta:STHERM_c05470 hypothetical protein; SMART: Helicase, ATP-dependent, c2 type; SPTR: Helicase c2.
      0.907
AEJ61502.1
KEGG: sta:STHERM_c11940 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.565
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 
 0.460
AEJ61390.1
Radical SAM domain protein; PFAM: Uncharacterized protein conserved in bacteria (DUF2344); Radical SAM superfamily; TIGRFAM: radical SAM-linked protein; COGs: COG1032 Fe-S oxidoreductase; InterPro IPR007197:IPR018768:IPR006638; KEGG: sta:STHERM_c10900 hypothetical protein; PFAM: Radical SAM; Protein of unknown function DUF2344; SMART: Elongator protein 3/MiaB/NifB; SPTR: Radical SAM domain protein.
  
    0.460
uvrC
UvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
    
 0.430
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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