STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (333 aa)    
Predicted Functional Partners:
bioD
Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
 
 
 0.996
AEJ61106.1
PFAM: Aminotransferase class-III; TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate transaminase; COGs: COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; InterPro IPR005814; KEGG: sta:STHERM_c13250 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: Aminotransferase class-III; SPTR: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; manually curated; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 0.977
birA
biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
  
 
 0.940
AEJ60767.1
PFAM: Radical SAM superfamily; TIGRFAM: iron-only hydrogenase maturation rSAM protein HydE; COGs: COG0502 Biotin synthase; InterPro IPR006638:IPR007197; KEGG: sta:STHERM_c17990 hypothetical protein; PFAM: Radical SAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: Radical SAM domain protein.
  
  
  0.932
AEJ62306.1
PFAM: Biotin/lipoate A/B protein ligase family; TIGRFAM: birA, biotin-[acetyl-CoA-carboxylase] ligase region; COGs: COG0340 Biotin-(acetyl-CoA carboxylase) ligase; InterPro IPR004143:IPR004408; KEGG: sta:STHERM_c19990 hypothetical protein; PFAM: Biotin/lipoate A/B protein ligase; SPTR: Biotin/acetyl-CoA-carboxylase ligase; TIGRFAM: Biotin--acetyl-CoA-carboxylase ligase.
  
 
 0.911
AEJ61105.1
PFAM: Aminotransferase class I and II; TIGRFAM: 8-amino-7-oxononanoate synthase; COGs: COG0156 7-keto-8-aminopelargonate synthetase; InterPro IPR004839; KEGG: sta:STHERM_c13260 hypothetical protein; PFAM: Aminotransferase, class I/II; SPTR: 8-amino-7-oxononanoate synthase.
  
 0.845
AEJ61519.1
PFAM: Cytochrome C assembly protein; InterPro IPR002541; KEGG: sta:STHERM_c12120 hypothetical protein; PFAM: Cytochrome c assembly protein; SPTR: Cytochrome c assembly protein.
       0.773
AEJ61520.1
KEGG: sta:STHERM_c12130 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.773
AEJ62342.1
PFAM: Aminotransferase class I and II; TIGRFAM: 8-amino-7-oxononanoate synthase; COGs: COG0156 7-keto-8-aminopelargonate synthetase; InterPro IPR004839; KEGG: sta:STHERM_c20440 8-amino-7-oxononanoate synthase; PFAM: Aminotransferase, class I/II; SPTR: Serine palmitoyltransferase.
  
 0.722
AEJ61103.1
Methyltransferase type 11; PFAM: Methyltransferase domain; TIGRFAM: biotin biosynthesis protein BioC; InterPro IPR013216; KEGG: sta:STHERM_c13280 biotin biosynthesis protein BioC; PFAM: Methyltransferase type 11; SPTR: Methyltransferase type 11.
  
     0.432
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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