Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cmk-2PFAM: Cytidylate kinase; TIGRFAM: cytidylate kinase, putative; COGs: COG1102 Cytidylate kinase; HAMAP: Cytidylate kinase; InterPro IPR000623:IPR011892; KEGG: sta:STHERM_c12230 cytidylate kinase; PFAM: Shikimate kinase; SPTR: Cytidylate kinase; TIGRFAM: Cytidylate kinase, putative. (172 aa)    
Predicted Functional Partners:
AEJ62063.1
PFAM: Nucleoside diphosphate kinase; COGs: COG0105 Nucleoside diphosphate kinase; InterPro IPR001564; KEGG: sta:STHERM_c17330 nucleoside-diphosphate kinase; PFAM: Nucleoside diphosphate kinase, core; SMART: Nucleoside diphosphate kinase, core; SPTR: Nucleoside diphosphate kinase; Belongs to the NDK family.
     
 0.904
AEJ60504.1
Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
    
  0.901
AEJ61127.1
Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
     
  0.900
surE
Multifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
  0.900
AEJ61504.1
TGS domain-containing protein; PFAM: Phosphoribulokinase / Uridine kinase family; COGs: COG0572 Uridine kinase; InterPro IPR003593:IPR004095; KEGG: sta:STHERM_c11970 hypothetical protein; PFAM: TGS; SMART: ATPase, AAA+ type, core; SPTR: TGS domain-containing protein.
    
  0.900
AEJ61526.1
Conserved hypothetical protein CHP00255; PFAM: YicC-like family, N-terminal region; Domain of unknown function (DUF1732); TIGRFAM: TIGR00255 family protein; COGs: COG1561 Uncharacterized stress-induced protein; InterPro IPR013527:IPR013551:IPR005229; KEGG: sta:STHERM_c12240 protein YicC; PFAM: YicC-like, N-terminal; Domain of unknown function DUF1732; SPTR: YicC-like domain-containing protein; TIGRFAM: Conserved hypothetical protein CHP00255.
       0.806
murC
UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family.
       0.806
rplK
Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
   
    0.764
rplV
Ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
  
    0.756
rplN
Ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family.
  
    0.749
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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