STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ61538.1PFAM: Stage II sporulation protein E (SpoIIE); InterPro IPR010822; KEGG: sta:STHERM_c12350 hypothetical protein; PFAM: Sporulation stage II, protein E C-terminal; SPTR: Putative uncharacterized protein. (396 aa)    
Predicted Functional Partners:
AEJ61539.1
Fe-S cluster domain protein; PFAM: Iron only hydrogenase large subunit, C-terminal domain; Putative Fe-S cluster; COGs: COG4624 Iron only hydrogenase large subunit C-terminal domain; InterPro IPR001450:IPR007202; KEGG: sta:STHERM_c12360 hypothetical protein; PFAM: Putative Fe-S cluster; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; SPTR: Fe-S cluster domain protein.
 
     0.955
AEJ61540.1
Hypothetical protein; PFAM: Respiratory-chain NADH dehydrogenase 24 Kd subunit; KEGG: sta:STHERM_c12370 hypothetical protein; SPTR: Putative uncharacterized protein.
 
     0.954
AEJ61537.1
Hypothetical protein; PFAM: Respiratory-chain NADH dehydrogenase 24 Kd subunit; KEGG: sta:STHERM_c12340 hypothetical protein; SPTR: Putative uncharacterized protein.
 
     0.940
AEJ61536.1
PFAM: Iron only hydrogenase large subunit, C-terminal domain; 4Fe-4S binding domain; COGs: COG4624 Iron only hydrogenase large subunit C-terminal domain; InterPro IPR001450:IPR004108; KEGG: sta:STHERM_c12330 hypothetical protein; PFAM: Iron hydrogenase, large subunit, C-terminal; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; SPTR: Hydrogenase large subunit domain protein.
 
     0.927
AEJ61777.1
Putative signal transduction protein with CBS domains; PFAM: CBS domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; COGs: COG2524 transcriptional regulator protein; InterPro IPR000644:IPR003594; KEGG: sta:STHERM_c13810 transcriptional regulatory protein; PFAM: Cystathionine beta-synthase, core; ATP-binding region, ATPase-like; SMART: Cystathionine beta-synthase, core; SPTR: Putative signal transduction protein with CBS domains.
 
 
 0.799
AEJ60715.1
Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: EAL domain; Response regulator receiver domain; GGDEF domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG2200 FOG: EAL domain; InterProIPR000014:IPR000160:IPR001789:IPR001633:IPR 013767; KEGG: sta:STHERM_c04670 hypothetical protein; PFAM: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; Signal transduction response regulator, receiver region; PAS fold; SMART: Diguanylate phosphodiesterase, predicted; Diguanylate cyclas [...]
  
  
 0.775
AEJ60492.1
Multi-sensor hybrid histidine kinase; PFAM: 7TM diverse intracellular signalling; Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; Hpt domain; COGs: COG0642 Signal transduction histidine kinase; InterPro IPR003661:IPR003594:IPR001789:IPR008207; KEGG: sta:STHERM_c02220 histidine kinase; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; Signal transduction response regulator, receiver region; Signal transduction histidine kinase, p [...]
  
  
 0.725
AEJ61090.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; Hpt domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR013656:IPR003661:IPR003594:IPR 001789:IPR008207; KEGG: sta:STHERM_c14170 two-component system, sensor histidine kinase; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; PAS fold-4; Signal transduction response regulator, receiver region; Signal transducti [...]
  
  
 0.725
AEJ60766.1
PFAM: Radical SAM superfamily; Biotin and Thiamin Synthesis associated domain; TIGRFAM: iron-only hydrogenase maturation rSAM protein HydG; thiazole biosynthesis protein ThiH; COGs: COG1060 Thiamine biosynthesis protein ThiH; InterPro IPR007197:IPR010722; KEGG: sta:STHERM_c18000 hypothetical protein; PFAM: Biotin/thiamin synthesis-associated protein; Radical SAM; SPTR: Iron-only hydrogenase maturation protein HydG.
  
  
 0.676
AEJ62530.1
ATP-binding region ATPase domain protein; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; InterPro IPR003594; KEGG: sta:STHERM_c22300 hypothetical protein; PFAM: ATP-binding region, ATPase-like; SPTR: ATP-binding region ATPase domain protein.
  
 
 0.637
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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