STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ61583.1AMP-dependent synthetase and ligase; PFAM: AMP-binding enzyme; COGs: COG1022 Long-chain acyl-CoA synthetase (AMP-forming); InterPro IPR000873; KEGG: sta:STHERM_c08540 hypothetical protein; PFAM: AMP-dependent synthetase/ligase; SPTR: AMP-dependent synthetase and ligase. (636 aa)    
Predicted Functional Partners:
AEJ60571.1
AMP-dependent synthetase and ligase; PFAM: AMP-binding enzyme; COGs: COG1022 Long-chain acyl-CoA synthetase (AMP-forming); InterPro IPR000873; KEGG: sta:STHERM_c03010 AMP-binding enzyme family protein; PFAM: AMP-dependent synthetase/ligase; SPTR: AMP-dependent synthetase and ligase.
  
  
 
0.927
AEJ61811.1
AMP-dependent synthetase and ligase; PFAM: AMP-binding enzyme; COGs: COG1022 Long-chain acyl-CoA synthetase (AMP-forming); InterPro IPR000873; KEGG: sta:STHERM_c14120 hypothetical protein; PFAM: AMP-dependent synthetase/ligase; SPTR: AMP-dependent synthetase and ligase.
  
  
 
0.906
AEJ61492.1
Alpha/beta hydrolase fold containing protein; PFAM: Putative lysophospholipase; COGs: COG2267 Lysophospholipase; InterPro IPR000073; KEGG: sta:STHERM_c11840 hypothetical protein; PFAM: Alpha/beta hydrolase fold-1; SPTR: Alpha/beta hydrolase fold protein.
    
  0.800
AEJ62217.1
Alpha/beta hydrolase fold containing protein; PFAM: Putative lysophospholipase; COGs: COG2267 Lysophospholipase; InterPro IPR000073; KEGG: sta:STHERM_c19130 hypothetical protein; PFAM: Alpha/beta hydrolase fold-1; SPTR: Alpha/beta hydrolase fold protein.
    
  0.800
AEJ61582.1
Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA/FabZ; PFAM: FabA-like domain; COGs: COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase; InterPro IPR013114; KEGG: sta:STHERM_c08550 beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; PFAM: Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase, FabA/FabZ; SPTR: Beta-hydroxyacyl-(Acyl-carrier-protein) dehydratase FabA/FabZ.
     
 0.626
rplE
Ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
    
 
 0.535
AEJ61580.1
PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; Biotin carboxylase C-terminal domain; Carbamoyl-phosphate synthase L chain, N-terminal domain; TIGRFAM: acetyl-CoA carboxylase, biotin carboxylase subunit; COGs: COG4770 Acetyl/propionyl-CoA carboxylase alpha subunit; InterPro IPR005481:IPR005479:IPR005482:IPR004549; KEGG: sta:STHERM_c08570 pyruvate carboxylase subunit A; PFAM: Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthase, large subunit, N-terminal; Biotin carboxylase, C-terminal; SPTR: Biotin carboxylase; acetyl-CoA carboxylase [...]
    
 0.467
rplR
Ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
    
 
 0.458
accA
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
       0.411
accD
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family.
       0.411
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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