STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
AEJ61605.1Integral membrane sensor signal transduction histidine kinase; PFAM: Histidine kinase; HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; COGs: COG2972 signal transduction protein with a C-terminal ATPase domain; InterPro IPR003660:IPR003594:IPR010559; KEGG: sta:STHERM_c08300 hypothetical protein; PFAM: Signal transduction histidine kinase, internal region; HAMP linker domain; ATP-binding region, ATPase-like; SMART: ATP-binding region, ATPase-like; HAMP linker domain; SPTR: Integral membrane sensor signal transduction histidine kinase. (642 aa)    
Predicted Functional Partners:
AEJ61604.1
Two component transcriptional regulator, AraC family; PFAM: Response regulator receiver domain; Bacterial regulatory helix-turn-helix proteins, AraC family; COGs: COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain; InterPro IPR001789:IPR018060:IPR000005; KEGG: sta:STHERM_c08310 hypothetical protein; PFAM: Signal transduction response regulator, receiver region; Helix-turn-helix, AraC type; SMART: Signal transduction response regulator, receiver region; Helix-turn-helix, AraC domain; SPTR: Two component transcriptional regulator, AraC family.
 
  
 0.886
AEJ61603.1
PFAM: family; TIGRFAM: rhamnose ABC transporter, rhamnose-binding protein; COGs: COG1879 ABC-type sugar transport system periplasmic component; InterPro IPR013459; KEGG: sta:STHERM_c08320 transporter; SPTR: Rhamnose-binding protein; TIGRFAM: Rhamnose ABC transporter, rhamnose-binding.
  
 
 0.762
AEJ61607.1
PFAM: FGGY family of carbohydrate kinases, N-terminal domain; FGGY family of carbohydrate kinases, C-terminal domain; COGs: COG1070 Sugar (pentulose and hexulose) kinase; InterPro IPR018484; KEGG: sta:STHERM_c08280 hypothetical protein; PFAM: Carbohydrate kinase, FGGY, N-terminal; SPTR: Carbohydrate kinase, FGGY.
       0.742
AEJ61606.1
PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase; COGs: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenase; InterPro IPR013154:IPR013149; KEGG: sta:STHERM_c08290 L-sorbose 1-phosphate reductase; PFAM: Alcohol dehydrogenase, zinc-binding; Alcohol dehydrogenase GroES-like; SPTR: Alcohol dehydrogenase zinc-binding domain protein.
     
 0.739
AEJ61610.1
Transketolase central region; PFAM: Dehydrogenase E1 component; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain; COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; InterPro IPR001017:IPR005475:IPR005476; KEGG: sta:STHERM_c08250 dehydrogenase, fusion; PFAM: Transketolase-like, pyrimidine-binding domain; Dehydrogenase, E1 component; Transketolase, C-terminal; SPTR: Transketolase central region.
       0.726
AEJ61608.1
Short-chain dehydrogenase/reductase SDR; PFAM: short chain dehydrogenase; COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002198; KEGG: sta:STHERM_c08270 hypothetical protein; PFAM: Short-chain dehydrogenase/reductase SDR; SPTR: Short-chain dehydrogenase/reductase SDR.
       0.721
AEJ61609.1
Hypothetical protein; PFAM: PHP domain; KEGG: sta:STHERM_c08260 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.721
AEJ61594.1
Two component transcriptional regulator, AraC family; PFAM: Response regulator receiver domain; Bacterial regulatory helix-turn-helix proteins, AraC family; COGs: COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain; InterPro IPR001789:IPR018060:IPR000005; KEGG: sta:STHERM_c08420 transcriptional regulatory protein; PFAM: Signal transduction response regulator, receiver region; Helix-turn-helix, AraC type; SMART: Helix-turn-helix, AraC domain; Signal transduction response regulator, receiver region; SPTR: Two component transcriptional regulato [...]
 
  
 0.675
AEJ61459.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; InterProIPR001789:IPR013767:IPR003661:IPR003594:IPR 000014; KEGG: sta:STHERM_c11530 hypothetical protein; PFAM: ATP-binding region, ATPase-like; Signal transduction response regulator, receiver region; PAS fold; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; SMART: Signal transdu [...]
  
  
 0.657
AEJ62396.1
PFAM: Bacterial regulatory helix-turn-helix proteins, AraC family; COGs: COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain; InterPro IPR000005:IPR018060; KEGG: sta:STHERM_c20960 transcriptional regulatory protein; PFAM: Helix-turn-helix, AraC type; SMART: Helix-turn-helix, AraC domain; SPTR: Transcriptional regulator, AraC family.
 
  
 0.638
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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