STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ61608.1Short-chain dehydrogenase/reductase SDR; PFAM: short chain dehydrogenase; COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002198; KEGG: sta:STHERM_c08270 hypothetical protein; PFAM: Short-chain dehydrogenase/reductase SDR; SPTR: Short-chain dehydrogenase/reductase SDR. (387 aa)    
Predicted Functional Partners:
AEJ61606.1
PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase; COGs: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenase; InterPro IPR013154:IPR013149; KEGG: sta:STHERM_c08290 L-sorbose 1-phosphate reductase; PFAM: Alcohol dehydrogenase, zinc-binding; Alcohol dehydrogenase GroES-like; SPTR: Alcohol dehydrogenase zinc-binding domain protein.
 
 
 0.990
AEJ61609.1
Hypothetical protein; PFAM: PHP domain; KEGG: sta:STHERM_c08260 hypothetical protein; SPTR: Putative uncharacterized protein.
 
     0.941
AEJ61610.1
Transketolase central region; PFAM: Dehydrogenase E1 component; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain; COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; InterPro IPR001017:IPR005475:IPR005476; KEGG: sta:STHERM_c08250 dehydrogenase, fusion; PFAM: Transketolase-like, pyrimidine-binding domain; Dehydrogenase, E1 component; Transketolase, C-terminal; SPTR: Transketolase central region.
 
 
 0.935
AEJ60705.1
PfkB domain protein; PFAM: pfkB family carbohydrate kinase; COGs: COG0524 Sugar kinase ribokinase family; InterPro IPR011611; KEGG: ace:Acel_2120 ribokinase-like domain-containing protein; PFAM: Carbohydrate/purine kinase; SPTR: PfkB domain protein.
  
 0.913
pfkA
6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
    
 0.907
pfp
Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
    
 0.907
pfkA-2
Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.
    
 0.907
AEJ61598.1
Class II aldolase/adducin family protein; PFAM: Class II Aldolase and Adducin N-terminal domain; COGs: COG3347 conserved hypothetical protein; InterPro IPR001303; KEGG: sta:STHERM_c08370 short chain dehydrogenase; PFAM: Class II aldolase/adducin, N-terminal; SPTR: Class II aldolase/adducin family protein.
     0.907
pfp-2
Diphosphate/fructose-6-phosphate1- phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
    
 0.907
AEJ62078.1
PFAM: Phosphomannose isomerase type I; TIGRFAM: mannose-6-phosphate isomerase, class I; COGs: COG1482 Phosphomannose isomerase; InterPro IPR001250; KEGG: sta:STHERM_c17490 mannose-6-phosphate isomerase; PFAM: Mannose-6-phosphate isomerase, type I; SPTR: Mannose-6-phosphate isomerase, class I; TIGRFAM: Mannose-6-phosphate isomerase, type I.
   
 
 0.904
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.