STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ61628.1Methyltransferase; PFAM: Conserved hypothetical protein 95; TIGRFAM: RNA methyltransferase, RsmD family; COGs: COG0742 N6-adenine-specific methylase; InterPro IPR016065:IPR004398; KEGG: sta:STHERM_c08060 hypothetical protein; PFAM: Protein of unknown function methylase putative; SPTR: Methyltransferase; TIGRFAM: Conserved hypothetical protein CHP00095. (180 aa)    
Predicted Functional Partners:
AEJ61626.1
Protein of unknown function YGGT; PFAM: YGGT family; InterPro IPR003425; KEGG: sta:STHERM_c08080 hypothetical protein; PFAM: Protein of unknown function YGGT; SPTR: Putative uncharacterized protein.
 
     0.830
coaD
Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.
 
  
 0.821
recG
ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily.
       0.806
AEJ61625.1
PFAM: Bacterial DNA polymerase III alpha subunit; PHP domain; OB-fold nucleic acid binding domain; TIGRFAM: DNA-directed DNA polymerase III (polc); COGs: COG0587 DNA polymerase III alpha subunit; InterProIPR003141:IPR004013:IPR011708:IPR004365:IPR 004805; KEGG: sta:STHERM_c08090 DNA polymerase III subunit alpha; PFAM: Bacterial DNA polymerase III, alpha subunit; PHP, C-terminal; Nucleic acid binding, OB-fold, tRNA/helicase-type; SMART: Polymerase/histidinol phosphatase, N-terminal; SPTR: DNA polymerase III, alpha subunit; TIGRFAM: DNA polymerase III, alpha subunit.
       0.731
AEJ61629.1
tRNA synthetase class II (G H P and S); COGs: COG3705 ATP phosphoribosyltransferase involved in histidine biosynthesis; InterPro IPR002314; KEGG: sta:STHERM_c08050 ATP phosphoribosyltransferase regulatory subunit; PFAM: Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved region; SPTR: tRNA synthetase class II (G H P and S).
       0.730
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
       0.730
hisB
PFAM: Imidazoleglycerol-phosphate dehydratase; COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; HAMAP: Imidazoleglycerol-phosphate dehydratase; InterPro IPR000807; KEGG: sta:STHERM_c08030 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase; SPTR: Imidazoleglycerol-phosphate dehydratase.
       0.706
AEJ60294.1
UPF0161 protein yidD; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family.
  
    0.688
AEJ61398.1
Pseudouridine synthase Rsu; PFAM: RNA pseudouridylate synthase; S4 domain; TIGRFAM: pseudouridine synthase; COGs: COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthase; InterPro IPR002942:IPR006145:IPR000748; KEGG: sta:STHERM_c10980 pseudouridylate synthase; PFAM: RNA-binding S4; Pseudouridine synthase, RsuA and RluB/C/D/E/F; SMART: RNA-binding S4; SPTR: Pseudouridine synthase; TIGRFAM: Pseudouridine synthase, RsuA and RluB/E/F; manually curated.
 
     0.548
tig
Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily.
  
     0.535
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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