STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ61634.1PFAM: Radical SAM superfamily; TIGRFAM: 23S rRNA m2A2503 methyltransferase; COGs: COG0820 Fe-S-cluster redox enzyme; InterPro IPR007197:IPR004383; KEGG: sta:STHERM_c08000 radical SAM enzyme, Cfr family; PFAM: Radical SAM; SPTR: Radical SAM enzyme, Cfr family; TIGRFAM: Ribosomal RNA large subunit methyltransferase RlmN. (354 aa)    
Predicted Functional Partners:
AEJ61633.1
Tetratricopeptide TPR_2 repeat-containing protein; PFAM: Tetratricopeptide repeat; COGs: COG2956 N-acetylglucosaminyl transferase; InterPro IPR019734:IPR001440:IPR013105; KEGG: sta:STHERM_c08010 TPR domain-containing protein; PFAM: Tetratricopeptide TPR2; Tetratricopeptide TPR-1; SMART: Tetratricopeptide repeat; SPTR: TPR domain protein.
       0.799
rimO
Ribosomal protein S12 methylthiotransferase rimO; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily.
 
  
 0.717
AEJ61436.1
Oxygen-independent coproporphyrinogen III oxidase; PFAM: Radical SAM superfamily; HemN C-terminal region; TIGRFAM: putative oxygen-independent coproporphyrinogen III oxidase; COGs: COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductase; InterPro IPR007197:IPR010723:IPR004559:IPR006638; KEGG: sta:STHERM_c11340 oxygen-independent coproporphyrinogen III oxidase; PFAM: Radical SAM; HemN, C-terminal; SMART: Elongator protein 3/MiaB/NifB; SPTR: Oxygen-independent coproporphyrinogen III oxidase; TIGRFAM: Putative oxygen-independent coproporphyrinogen III oxidase.
 
   
 0.683
miaB
(Dimethylallyl)adenosine tRNA methylthiotransferase miaB; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
 
  
 0.679
AEJ61564.1
MiaB-like tRNA modifying enzyme; PFAM: Radical SAM superfamily; Uncharacterized protein family UPF0004; TIGRFAM: MiaB-like tRNA modifying enzyme; radical SAM methylthiotransferase, MiaB/RimO family; COGs: COG0621 2-methylthioadenine synthetase; InterProIPR006638:IPR013848:IPR007197:IPR005839:IPR 006467; KEGG: sta:STHERM_c08730 hypothetical protein; PFAM: Radical SAM; Methylthiotransferase, N-terminal; SMART: Elongator protein 3/MiaB/NifB; SPTR: MiaB-like tRNA modifying enzyme; TIGRFAM: MiaB-like tRNA modifying enzyme; Methylthiotransferase.
 
  
 0.677
AEJ61632.1
KEGG: sta:STHERM_c08020 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.677
nusB
NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
  
  
 0.561
fmt
Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
  
    0.554
efp
Elongation factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
  
  
 0.516
AEJ62041.1
Protein of unknown function UPF0001; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
 
     0.459
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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