PFAM: Putative small multi-drug export protein; COGs: COG2426 membrane protein; InterPro IPR009577; KEGG: sta:STHERM_c07950 small multidrug export protein QacE; PFAM: Putative small multi-drug export; SPTR: Small multi-drug export protein.

UvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...]

PFAM: NUDIX domain; InterPro IPR000086; KEGG: sta:STHERM_c07930 hypothetical protein; PFAM: NUDIX hydrolase domain; SPTR: NUDIX hydrolase.

DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]

Protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.

Putative PTS IIA-like nitrogen-regulatory protein PtsN; PFAM: CBS domain; Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; COGs: COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); InterPro IPR000644:IPR002178; KEGG: sta:STHERM_c07970 hypothetical protein; PFAM: Cystathionine beta-synthase, core; Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2; SMART: Cystathionine beta-synthase, core; SPTR: Putative PTS IIA-like nitrogen-regulatory protein PtsN.

DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]

DNA mismatch repair protein mutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

PFAM: Citrate transporter; COGs: COG1055 Na+/H+ antiporter NhaD and related arsenite permease; InterPro IPR004680; KEGG: sta:STHERM_c07960 hypothetical protein; PFAM: Divalent ion symporter; SPTR: Possible tyrosine transporter P-protein.