Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEJ61639.1PFAM: UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212; KEGG: sta:STHERM_c07940 hypothetical protein; PFAM: DNA helicase, UvrD/REP type; SPTR: UvrD/REP helicase. (665 aa)    
Predicted Functional Partners:
AEJ62422.1
PFAM: UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212; KEGG: sta:STHERM_c21210 DNA helicase; PFAM: DNA helicase, UvrD/REP type; SPTR: UvrD/REP helicase.
  
  
 
0.916
AEJ61638.1
PFAM: Putative small multi-drug export protein; COGs: COG2426 membrane protein; InterPro IPR009577; KEGG: sta:STHERM_c07950 small multidrug export protein QacE; PFAM: Putative small multi-drug export; SPTR: Small multi-drug export protein.
       0.801
AEJ61640.1
PFAM: NUDIX domain; InterPro IPR000086; KEGG: sta:STHERM_c07930 hypothetical protein; PFAM: NUDIX hydrolase domain; SPTR: NUDIX hydrolase.
     
 0.773
AEJ60289.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
 
 
 0.765
recA
Protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.723
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
 
 0.714
AEJ61636.1
Putative PTS IIA-like nitrogen-regulatory protein PtsN; PFAM: CBS domain; Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; COGs: COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); InterPro IPR000644:IPR002178; KEGG: sta:STHERM_c07970 hypothetical protein; PFAM: Cystathionine beta-synthase, core; Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2; SMART: Cystathionine beta-synthase, core; SPTR: Putative PTS IIA-like nitrogen-regulatory protein PtsN.
       0.678
mutL
DNA mismatch repair protein mutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
   
 
 0.668
uvrC
UvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
 
  
 0.666
AEJ61637.1
PFAM: Citrate transporter; COGs: COG1055 Na+/H+ antiporter NhaD and related arsenite permease; InterPro IPR004680; KEGG: sta:STHERM_c07960 hypothetical protein; PFAM: Divalent ion symporter; SPTR: Possible tyrosine transporter P-protein.
       0.663
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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