STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ61641.1Hydrolase, TatD family; PFAM: TatD related DNase; TIGRFAM: hydrolase, TatD family; COGs: COG0084 Mg-dependent DNase; InterPro IPR001130:IPR015991; KEGG: sta:STHERM_c07890 hypothetical protein; PFAM: Deoxyribonuclease, TatD-related; SPTR: Hydrolase, TatD family; TIGRFAM: Deoxyribonuclease, TatD Mg-dependent, prokaryote. (266 aa)    
Predicted Functional Partners:
AEJ61208.1
PFAM: Flagellar hook-basal body complex protein FliE; TIGRFAM: flagellar hook-basal body complex protein FliE; COGs: COG1677 Flagellar hook-basal body protein; InterPro IPR001624; KEGG: sta:STHERM_c09090 flagellar hook-basal body complex protein FliE; PFAM: Flagellar hook-basal body complex protein FliE; SPTR: Flagellar hook-basal body complex subunit FliE; TIGRFAM: Flagellar hook-basal body complex protein FliE.
   
 
 0.657
metG
Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
 
 0.556
AEJ61640.1
PFAM: NUDIX domain; InterPro IPR000086; KEGG: sta:STHERM_c07930 hypothetical protein; PFAM: NUDIX hydrolase domain; SPTR: NUDIX hydrolase.
  
    0.531
AEJ61707.1
PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Aspartate carbamoyltransferase regulatory chain, metal binding domain; Aspartate carbamoyltransferase regulatory chain, allosteric domain; TIGRFAM: aspartate carbamoyltransferase; COGs: COG0540 Aspartate carbamoyltransferase catalytic chain; InterProIPR006132:IPR006131:IPR020545:IPR020542:IPR 002082; KEGG: sta:STHERM_c07130 hypothetical protein; PFAM: Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; Aspartate/ornithine carbamoylt [...]
  
    0.508
AEJ61639.1
PFAM: UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212; KEGG: sta:STHERM_c07940 hypothetical protein; PFAM: DNA helicase, UvrD/REP type; SPTR: UvrD/REP helicase.
       0.504
ffh
Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily.
 
  
 0.499
AEJ61638.1
PFAM: Putative small multi-drug export protein; COGs: COG2426 membrane protein; InterPro IPR009577; KEGG: sta:STHERM_c07950 small multidrug export protein QacE; PFAM: Putative small multi-drug export; SPTR: Small multi-drug export protein.
       0.488
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
 
  
 0.487
AEJ61636.1
Putative PTS IIA-like nitrogen-regulatory protein PtsN; PFAM: CBS domain; Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; COGs: COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); InterPro IPR000644:IPR002178; KEGG: sta:STHERM_c07970 hypothetical protein; PFAM: Cystathionine beta-synthase, core; Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2; SMART: Cystathionine beta-synthase, core; SPTR: Putative PTS IIA-like nitrogen-regulatory protein PtsN.
       0.479
AEJ61934.1
uroporphyrin-III C-methyltransferase; PFAM: Porphobilinogen deaminase, dipyromethane cofactor binding domain; Tetrapyrrole (Corrin/Porphyrin) Methylases; Uroporphyrinogen-III synthase HemD; TIGRFAM: porphobilinogen deaminase; uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR006366:IPR000860:IPR000878:IPR003754; KEGG: sta:STHERM_c16140 porphyrin biosynthesis protein HemD; PFAM: Tetrapyrrole methylase; Tetrapyrrole biosynthesis, hydroxymethylbilane synthase; Tetrapyrrole biosynthesis, uroporphyrinogen III synthase; SPTR: Uroporphyrin-III C-m [...]
  
  
 0.474
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.