STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ61645.1PFAM: Fructose-bisphosphate aldolase class-II; TIGRFAM: ketose-bisphosphate aldolases; fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; COGs: COG0191 Fructose/tagatose bisphosphate aldolase; InterPro IPR000771:IPR011289; KEGG: sta:STHERM_c07850 fructose-bisphosphate aldolase; PFAM: Ketose-bisphosphate aldolase, class-II; SPTR: Fructose-bisphosphate aldolase; TIGRFAM: Fructose-1,6-bisphosphate aldolase, class II; Ketose-bisphosphate aldolase, class-II. (330 aa)    
Predicted Functional Partners:
AEJ61276.1
PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; COGs: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; InterPro IPR020828:IPR020829:IPR006424; KEGG: sta:STHERM_c09790 glyceraldehyde-3-phosphate dehydrogenase; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; SPTR: Glyceraldehyde-3-phosphate dehydrogenase; TIGRFAM: Glyceraldehyde-3-p [...]
  
 0.988
tpiA
Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
  
 
 0.986
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
  
 0.974
pgi
PFAM: Phosphoglucose isomerase; COGs: COG0166 Glucose-6-phosphate isomerase; HAMAP: Phosphoglucose isomerase (PGI); InterPro IPR001672; KEGG: sta:STHERM_c20070 glucose-6-phosphate isomerase; PFAM: Phosphoglucose isomerase (PGI); SPTR: Glucose-6-phosphate isomerase; Belongs to the GPI family.
  
 
 0.969
AEJ60409.1
Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
  
 
 0.957
AEJ62080.1
PfkB domain protein; PFAM: pfkB family carbohydrate kinase; TIGRFAM: hexose kinase, 1-phosphofructokinase family; COGs: COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB); InterPro IPR011611; KEGG: sta:STHERM_c17500 sugar kinase; PFAM: Carbohydrate/purine kinase; SPTR: PfkB domain protein.
  
 
 0.941
pgk
PFAM: Phosphoglycerate kinase; COGs: COG0126 3-phosphoglycerate kinase; HAMAP: Phosphoglycerate kinase; InterPro IPR001576; KEGG: sta:STHERM_c09800 phosphoglycerate kinase; PFAM: Phosphoglycerate kinase; SPTR: Phosphoglycerate kinase.
  
 
 0.924
pfkA
6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
  
 
 0.922
pfp
Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
  
 
 0.922
pfkA-2
Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.
  
 
 0.922
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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