STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ61696.1PFAM: PHP domain; COGs: COG0613 metal-dependent phosphoesterase (PHP family); InterPro IPR003141:IPR004013; KEGG: sta:STHERM_c07240 hypothetical protein; PFAM: PHP, C-terminal; SMART: Polymerase/histidinol phosphatase, N-terminal; SPTR: PHP domain protein. (283 aa)    
Predicted Functional Partners:
rnc
Ribonuclease 3; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
     0.907
AEJ61702.1
PFAM: Peptidase family M23; LysM domain; COGs: COG0739 Membrane protein related to metalloendopeptidase; InterPro IPR018392:IPR016047; KEGG: sta:STHERM_c07180 M23/M37 peptidase domain-containing protein; PFAM: Peptidase M23; Peptidoglycan-binding lysin domain; SPTR: Peptidase M23.
       0.787
AEJ61703.1
PFAM: PEGA domain; InterPro IPR013229; KEGG: sta:STHERM_c07170 hypothetical protein; PFAM: PEGA; SPTR: PEGA domain protein.
       0.786
AEJ61697.1
PFAM: Domain of unknown function DUF140; TIGRFAM: conserved hypothetical integral membrane protein; COGs: COG0767 ABC-type transport system involved in resistance to organic solvents permease component; InterPro IPR003453; KEGG: sta:STHERM_c07230 transporter; PFAM: Protein of unknown function DUF140; SPTR: Putative uncharacterized protein.
       0.778
AEJ61699.1
Mammalian cell entry related domain protein; PFAM: mce related protein; COGs: COG1463 ABC-type transport system involved in resistance to organic solvents periplasmic component; InterPro IPR003399; KEGG: sta:STHERM_c07210 hypothetical protein; PFAM: Mammalian cell entry related; SPTR: Mammalian cell entry related domain protein.
       0.778
AEJ61698.1
PFAM: ABC transporter; COGs: COG1127 ABC-type transport system involved in resistance to organic solvents ATPase component; InterPro IPR003593:IPR003439; KEGG: sta:STHERM_c07220 transporter; PFAM: ABC transporter-like; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related protein.
       0.776
AEJ61700.1
Tetratricopeptide TPR_2 repeat-containing protein; InterPro IPR019734:IPR013105:IPR001440; KEGG: sta:STHERM_c07200 hypothetical protein; PFAM: Tetratricopeptide TPR2; Tetratricopeptide TPR-1; SPTR: Tetratricopeptide TPR_1 repeat-containing protein.
       0.773
AEJ61701.1
KEGG: sta:STHERM_c07190 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.773
nusB
NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
 
    0.645
AEJ61695.1
Putative transcriptional regulator, Crp/Fnr family; PFAM: Cyclic nucleotide-binding domain; COGs: COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase; InterPro IPR000595; KEGG: sta:STHERM_c07250 cyclic nucleotide-binding protein; PFAM: Cyclic nucleotide-binding; SMART: Cyclic nucleotide-binding; SPTR: Putative transcriptional regulator, Crp/Fnr family.
       0.575
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
Server load: low (8%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.