STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nrdRTranscriptional repressor nrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (164 aa)    
Predicted Functional Partners:
AEJ61728.1
PFAM: ATP cone domain; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; COGs: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; InterPro IPR005144:IPR012833; KEGG: sta:STHERM_c06820 anaerobic ribonucleoside triphosphate reductase; PFAM: ATP-cone; SPTR: Anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: Ribonucleoside-triphosphate reductase, anaerobic.
     
 0.805
AEJ61729.1
PFAM: Glutaredoxin; InterPro IPR002109; KEGG: sta:STHERM_c06810 hypothetical protein; PFAM: Glutaredoxin; SPTR: Glutaredoxin.
     
 0.720
AEJ61730.1
PFAM: Radical SAM superfamily; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase activating protein; COGs: COG1180 Pyruvate-formate lyase-activating enzyme; InterPro IPR007197:IPR012840; KEGG: sta:STHERM_c06800 hypothetical protein; PFAM: Radical SAM; SPTR: Anaerobic ribonucleoside-triphosphate reductase activating protein; TIGRFAM: Ribonucleoside-triphosphate reductase, anaerobic-like.
       0.684
AEJ61726.1
PFAM: ArsC family; COGs: COG1393 Arsenate reductase and related protein glutaredoxin family; InterPro IPR006660; KEGG: sta:STHERM_c06840 hypothetical protein; PFAM: Arsenate reductase-like; SPTR: Arsenate reductase; Belongs to the ArsC family.
  
  
 0.554
AEJ60747.1
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
  
  
 0.547
AEJ60359.1
Alpha-2-macroglobulin domain protein; PFAM: Alpha-macro-globulin thiol-ester bond-forming region; MG2 domain; Alpha-2-macroglobulin family N-terminal region; Alpha-2-macroglobulin MG1 domain; COGs: COG2373 Large extracellular alpha-helical protein; InterPro IPR002890:IPR011625; KEGG: sta:STHERM_c00850 inner membrane lipoprotein; PFAM: Alpha-2-macroglobulin, N-terminal; Alpha-2-macroglobulin, N-terminal 2; SPTR: Alpha-2-macroglobulin domain protein.
    
   0.513
AEJ61725.1
Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP).
  
    0.450
ribBA
GTP cyclohydrolase-2; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
     
 0.434
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
     
 0.425
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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