Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEJ61839.1PFAM: Bacterial type II secretion system protein F domain; COGs: COG1459 Type II secretory pathway component PulF; InterPro IPR018076; KEGG: tam:Theam_0991 type II secretion system F domain protein; PFAM: Type II secretion system F domain; SPTR: Type II secretion system F domain. (398 aa)    
Predicted Functional Partners:
AEJ61840.1
PFAM: GSPII_E N-terminal domain; Type II/IV secretion system protein; COGs: COG2804 Type II secretory pathway ATPase PulE/Tfp pilus assembly pathway ATPase PilB; InterPro IPR007831:IPR001482; KEGG: cle:Clole_1716 type II secretion system protein E; PFAM: Type II secretion system protein E; General secretory system II, protein E, N-terminal; SPTR: Type II secretion system protein E.
 
 
 0.998
AEJ61838.1
PFAM: Bacterial type II secretion system protein G; TIGRFAM: general secretion pathway protein G; COGs: COG2165 Type II secretory pathway pseudopilin PulG; InterPro IPR012902:IPR010054:IPR013545; KEGG: general secretion pathway protein G; PFAM: Type II secretion system protein G; SPTR: General secretion pathway protein G; TIGRFAM: General secretion pathway protein G; Prepilin-type cleavage/methylation, N-terminal.
 
  
 0.994
AEJ61841.1
PFAM: Bacterial type II and III secretion system protein; COGs: COG1450 Type II secretory pathway component PulD; InterPro IPR004846; KEGG: type II and III secretion system protein; PFAM: Type II/III secretion system; SPTR: Type II and III secretion system protein; Belongs to the bacterial secretin family.
 
  
 0.952
AEJ61842.1
PFAM: Type IV leader peptidase family; InterPro IPR000045; KEGG: tna:CTN_0883 type IV prepilin peptidase; PFAM: Peptidase A24A, prepilin type IV; SPTR: Peptidase A24A prepilin type IV.
  
  
 0.830
AEJ61114.1
Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
 
  
 0.763
AEJ61201.1
PFAM: DNA recombination-mediator protein A; TIGRFAM: DNA protecting protein DprA; COGs: COG0758 Rossmann fold nucleotide-binding protein involved in DNA uptake; InterPro IPR003488; KEGG: sta:STHERM_c09020 DNA processing protein DprA; PFAM: DNA recombination-mediator protein A; SPTR: DNA protecting protein DprA; TIGRFAM: DNA recombination-mediator protein A.
 
  
 0.527
AEJ61572.1
PFAM: Competence protein; TIGRFAM: ComEC/Rec2-related protein; COGs: COG0658 membrane metal-binding protein; InterPro IPR004477; KEGG: sta:STHERM_c08650 hypothetical protein; PFAM: ComEC/Rec2-related protein; SPTR: ComEC/Rec2-related protein; TIGRFAM: ComEC/Rec2-related protein.
   
  
 0.519
AEJ61836.1
Hypothetical protein.
       0.490
AEJ60715.1
Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: EAL domain; Response regulator receiver domain; GGDEF domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG2200 FOG: EAL domain; InterProIPR000014:IPR000160:IPR001789:IPR001633:IPR 013767; KEGG: sta:STHERM_c04670 hypothetical protein; PFAM: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; Signal transduction response regulator, receiver region; PAS fold; SMART: Diguanylate phosphodiesterase, predicted; Diguanylate cyclas [...]
 
   
 0.488
AEJ61424.1
Phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: comF family protein; COGs: COG1040 amidophosphoribosyltransferase; InterPro IPR000836; KEGG: sta:STHERM_c11220 hypothetical protein; PFAM: Phosphoribosyltransferase; SPTR: Putative uncharacterized protein; manually curated.
  
  
 0.460
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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