STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hisSPFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: histidyl-tRNA synthetase; COGs: COG0124 Histidyl-tRNA synthetase; HAMAP: Histidyl-tRNA synthetase, class IIa, subgroup; InterPro IPR015807:IPR002314:IPR004154; KEGG: sta:STHERM_c15800 histidyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved region; Anticodon-binding; SPTR: Histidyl-tRNA synthetase; TIGRFAM: Histidyl-tRNA synthetase, class IIa, subgroup. (437 aa)    
Predicted Functional Partners:
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
 
 
 0.923
aspS
aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
  
  
 0.896
metG
Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
 
 
 0.826
argS
Arginyl-tRNA synthetase; PFAM: DALR anticodon binding domain; Arginyl tRNA synthetase N terminal domain; tRNA synthetases class I (R); TIGRFAM: arginyl-tRNA synthetase; COGs: COG0018 Arginyl-tRNA synthetase; HAMAP: Arginyl-tRNA synthetase, class Ic; InterPro IPR005148:IPR015945:IPR008909:IPR001278; KEGG: sta:STHERM_c10230 hypothetical protein; PFAM: Arginyl-tRNA synthetase, class Ic, core; Arginyl tRNA synthetase, class Ic, N-terminal; DALR anticodon binding; SPTR: Arginyl-tRNA synthetase; TIGRFAM: Arginyl-tRNA synthetase, class Ic.
 
  
 0.750
AEJ61894.1
Helicase-associated domain protein; PFAM: Helicase conserved C-terminal domain; Helicase associated domain (HA2); Domain of unknown function (DUF1605); DEAD/DEAH box helicase; TIGRFAM: ATP-dependent helicase HrpA; COGs: COG1643 HrpA-like helicase; InterPro IPR014001:IPR001650:IPR007502:IPR011709; KEGG: sta:STHERM_c15810 hypothetical protein; PFAM: Helicase-associated region; DNA/RNA helicase, C-terminal; Domain of unknown function DUF1605; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; SPTR: Helicase-associated domain protein.
 
 
 
 0.740
ispG
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family.
  
  
 0.703
ftsA
Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family.
  
    0.691
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
 
 
 0.689
cysS
PFAM: tRNA synthetases class I (C) catalytic domain; TIGRFAM: cysteinyl-tRNA synthetase; COGs: COG0215 Cysteinyl-tRNA synthetase; InterPro IPR015803:IPR002308; KEGG: sta:STHERM_c18260 hypothetical protein; PFAM: Cysteinyl-tRNA synthetase, class Ia, N-terminal; SPTR: Cysteinyl-tRNA synthetase; TIGRFAM: Cysteinyl-tRNA synthetase, class Ia; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 
 0.683
htpG
Chaperone protein htpG; Molecular chaperone. Has ATPase activity.
   
 
 0.681
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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