STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ61906.1Short-chain dehydrogenase/reductase SDR; PFAM: short chain dehydrogenase; COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002198; KEGG: ote:Oter_1273 short-chain dehydrogenase/reductase SDR; PFAM: Short-chain dehydrogenase/reductase SDR; SPTR: 5-keto-D-gluconate 5-reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (257 aa)    
Predicted Functional Partners:
AEJ60734.1
Short-chain dehydrogenase/reductase SDR; PFAM: short chain dehydrogenase; COGs: COG0300 Short-chain dehydrogenase of various substrate specificities; InterPro IPR002198; KEGG: sta:STHERM_c18100 estradiol 17-beta-dehydrogenase 12; PFAM: Short-chain dehydrogenase/reductase SDR; SPTR: Short-chain dehydrogenase/reductase SDR; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
 
 
 0.722
AEJ61591.1
PFAM: Bacterial alpha-L-rhamnosidase; Alpha-L-rhamnosidase N-terminal domain; InterPro IPR013737:IPR008902; KEGG: sta:STHERM_c08460 alfa-L-rhamnosidase; PFAM: Bacterial alpha-L-rhamnosidase; Bacterial alpha-L-rhamnosidase N-terminal; SPTR: Alpha-L-rhamnosidase.
   
 
 0.601
AEJ61907.1
PFAM: Bacterial regulatory proteins, gntR family; FCD domain; COGs: COG1802 Transcriptional regulators; InterPro IPR000524:IPR011711; KEGG: sta:STHERM_c04230 hypothetical protein; PFAM: HTH transcriptional regulator, GntR; GntR, C-terminal; SMART: HTH transcriptional regulator, GntR; SPTR: Transcriptional regulator, GntR family.
     
 0.580
AEJ62080.1
PfkB domain protein; PFAM: pfkB family carbohydrate kinase; TIGRFAM: hexose kinase, 1-phosphofructokinase family; COGs: COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB); InterPro IPR011611; KEGG: sta:STHERM_c17500 sugar kinase; PFAM: Carbohydrate/purine kinase; SPTR: PfkB domain protein.
  
  
 0.569
AEJ62280.1
Transketolase domain-containing protein; PFAM: Dehydrogenase E1 component; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; Transketolase, C-terminal domain; Biotin-requiring enzyme; Transketolase, pyrimidine binding domain; TIGRFAM: 3-oxoacyl-(acyl-carrier-protein) synthase III; COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; InterProIPR001017:IPR005475:IPR005476:IPR000089:IPR 013751:IPR013747; KEGG: sta:STHERM_c19760 hypothetical protein; PFAM: Tr [...]
  
 
 0.524
AEJ62292.1
PFAM: PTS system sugar-specific permease component; COGs: COG3775 Phosphotransferase system galactitol-specific IIC component; InterPro IPR004703; KEGG: sta:STHERM_c19850 hypothetical protein; PFAM: Phosphotransferase system, galactitol-specific IIC component; SPTR: PTS system Galactitol-specific IIC component.
  
    0.524
AEJ61908.1
Oxidoreductase domain protein; PFAM: Oxidoreductase family, NAD-binding Rossmann fold; Oxidoreductase family, C-terminal alpha/beta domain; COGs: COG0673 dehydrogenase and related protein; InterPro IPR000683:IPR004104; KEGG: rha:RHA1_ro08212 NADH-dependent oxidoreductase; PFAM: Oxidoreductase, N-terminal; Oxidoreductase, C-terminal; SPTR: Oxidoreductase domain protein.
  
  
 0.511
AEJ62453.1
PFAM: Acyl transferase domain; TIGRFAM: malonyl CoA-acyl carrier protein transacylase; COGs: COG0331 (acyl-carrier-protein) S-malonyltransferase; InterPro IPR004410:IPR014043; KEGG: sta:STHERM_c21550 hypothetical protein; PFAM: Acyl transferase; SPTR: Malonyl CoA-acyl carrier protein transacylase; TIGRFAM: Malonyl CoA-acyl carrier protein transacylase.
 
 
 0.510
AEJ62451.1
3-oxoacyl-(acyl-carrier-protein) synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.
  
 
 0.482
kduI
4-deoxy-L-threo-5-hexosulose-uronateketol- isomerase; Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate. Belongs to the KduI family.
 
  
 0.465
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.