Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AEJ61945.1UBA/THIF-type NAD/FAD binding protein; PFAM: MoeZ/MoeB domain; ThiF family; COGs: COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2; InterPro IPR000594:IPR007901; KEGG: sta:STHERM_c16250 hypothetical protein; PFAM: UBA/THIF-type NAD/FAD binding fold; MoeZ/MoeB; SPTR: UBA/THIF-type NAD/FAD binding protein. (271 aa)    
Predicted Functional Partners:
AEJ61947.1
PFAM: ThiS family; TIGRFAM: thiamine biosynthesis protein ThiS; InterPro IPR010035:IPR003749; KEGG: sta:STHERM_c16270 thiamine biosynthesis protein ThiS; PFAM: ThiamineS; SPTR: Thiamine biosynthesis protein ThiS; TIGRFAM: ThiS, thiamine-biosynthesis.
 
 
 0.978
AEJ61942.1
PFAM: Mov34/MPN/PAD-1 family; COGs: COG1310 metal-dependent protease of the PAD1/JAB1 superfamily; InterPro IPR000555; KEGG: sta:STHERM_c16220 Mov34/MPN/PAD-1 family protein; PFAM: Mov34/MPN/PAD-1; SMART: Mov34/MPN/PAD-1; SPTR: Mov34/MPN/PAD-1 family protein.
 
 0.965
AEJ60423.1
PFAM: ThiS family; TIGRFAM: thiamine biosynthesis protein ThiS; InterPro IPR003749:IPR010035; KEGG: sta:STHERM_c01480 hypothetical protein; PFAM: ThiamineS; SPTR: Thiamine biosynthesis protein ThiS; TIGRFAM: ThiS, thiamine-biosynthesis.
  
 
 0.955
AEJ61899.1
PFAM: Aminotransferase class-V; COGs: COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase; InterPro IPR000192; KEGG: sta:STHERM_c15870 cysteine desulfurase; PFAM: Aminotransferase, class V/Cysteine desulfurase; SPTR: Cysteine desulfurase.
   
 0.947
AEJ61943.1
PFAM: SirA-like protein; InterPro IPR001455; KEGG: sta:STHERM_c16230 hypothetical protein; PFAM: SirA-like; SPTR: SirA-like domain-containing protein; Belongs to the sulfur carrier protein TusA family.
 
   
 0.938
AEJ61937.1
Sulfate adenylyltransferase, large subunit; PFAM: Elongation factor Tu domain 2; Elongation factor Tu GTP binding domain; Adenylylsulphate kinase; TIGRFAM: sulfate adenylyltransferase, large subunit; COGs: COG2895 GTPase - Sulfate adenylate transferase subunit 1; InterPro IPR011779:IPR000795:IPR004161; KEGG: sta:STHERM_c16170 sulfate adenylyltransferase large subunit; PFAM: Protein synthesis factor, GTP-binding; Translation elongation factor EFTu/EF1A, domain 2; SPTR: Sulfate adenylyltransferase, large subunit; TIGRFAM: Sulphate adenylyltransferase, large subunit.
 
 
 0.891
thiG
Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.886
AEJ61941.1
PFAM: SirA-like protein; Nitrite and sulphite reductase 4Fe-4S domain; Nitrite/Sulfite reductase ferredoxin-like half domain; COGs: COG0155 Sulfite reductase beta subunit (hemoprotein); InterPro IPR005117:IPR006067:IPR001455; KEGG: sta:STHERM_c16210 ferredoxin-nitrite reductase; PFAM: Nitrite/sulphite reductase 4Fe-4S region; Nitrite/sulphite reductase, hemoprotein beta-component, ferrodoxin-like; SirA-like; SPTR: Ferredoxin--nitrite reductase.
 
   
 0.883
AEJ61934.1
uroporphyrin-III C-methyltransferase; PFAM: Porphobilinogen deaminase, dipyromethane cofactor binding domain; Tetrapyrrole (Corrin/Porphyrin) Methylases; Uroporphyrinogen-III synthase HemD; TIGRFAM: porphobilinogen deaminase; uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR006366:IPR000860:IPR000878:IPR003754; KEGG: sta:STHERM_c16140 porphyrin biosynthesis protein HemD; PFAM: Tetrapyrrole methylase; Tetrapyrrole biosynthesis, hydroxymethylbilane synthase; Tetrapyrrole biosynthesis, uroporphyrinogen III synthase; SPTR: Uroporphyrin-III C-m [...]
 
    0.842
AEJ61940.1
Protein of unknown function DUF2061, membrane; PFAM: Predicted membrane protein (DUF2061); InterPro IPR018638; KEGG: sta:STHERM_c16200 hypothetical protein; PFAM: Protein of unknown function DUF2061, membrane; SPTR: Putative uncharacterized protein.
  
 
 0.838
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.