STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
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[Homology]
Score
fabVReductase; Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA); Belongs to the TER reductase family. (392 aa)    
Predicted Functional Partners:
AEJ61582.1
Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA/FabZ; PFAM: FabA-like domain; COGs: COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase; InterPro IPR013114; KEGG: sta:STHERM_c08550 beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; PFAM: Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase, FabA/FabZ; SPTR: Beta-hydroxyacyl-(Acyl-carrier-protein) dehydratase FabA/FabZ.
  
 
 0.940
AEJ62451.1
3-oxoacyl-(acyl-carrier-protein) synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.
  
 
 0.939
AEJ60373.1
PFAM: Acyl-ACP thioesterase; COGs: COG3884 Acyl-ACP thioesterase; InterPro IPR002864; KEGG: sta:STHERM_c00990 acyl-ACP thioesterase; PFAM: Acyl-ACP thioesterase; SPTR: Acyl-ACP thioesterase.
     
 0.903
AEJ62456.1
PFAM: subunit; TIGRFAM: sodium ion-translocating decarboxylase, beta subunit; COGs: COG1883 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase beta subunit; InterPro IPR005661; KEGG: sta:STHERM_c21580 oxaloacetate decarboxylase subunit beta; PFAM: Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit; SPTR: Sodium ion-translocating decarboxylase, beta subunit; TIGRFAM: Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit.
     
  0.900
lipB
Octanoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
     
  0.800
xylA
PFAM: Xylose isomerase-like TIM barrel; TIGRFAM: xylose isomerase; COGs: COG2115 Xylose isomerase; HAMAP: Xylose isomerase; InterPro IPR013452:IPR012307:IPR001998; KEGG: sta:STHERM_c16290 xylose isomerase; PFAM: Xylose isomerase, TIM barrel domain; SPTR: Xylose isomerase; TIGRFAM: Xylose isomerase, bacterial type; Belongs to the xylose isomerase family.
       0.520
AEJ61951.1
HflK protein; HflC and HflK could encode or regulate a protease.
       0.518
AEJ61952.1
HflC protein; HflC and HflK could regulate a protease.
       0.518
AEJ62453.1
PFAM: Acyl transferase domain; TIGRFAM: malonyl CoA-acyl carrier protein transacylase; COGs: COG0331 (acyl-carrier-protein) S-malonyltransferase; InterPro IPR004410:IPR014043; KEGG: sta:STHERM_c21550 hypothetical protein; PFAM: Acyl transferase; SPTR: Malonyl CoA-acyl carrier protein transacylase; TIGRFAM: Malonyl CoA-acyl carrier protein transacylase.
  
  
 0.457
accA
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
  
  
 0.435
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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