STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ61954.1Diguanylate cyclase/phosphodiesterase; PFAM: EAL domain; GGDEF domain; COGs: COG2200 FOG: EAL domain; InterPro IPR000160:IPR001633; KEGG: sta:STHERM_c16340 hypothetical protein; PFAM: Diguanylate phosphodiesterase, predicted; SMART: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; SPTR: Diguanylate cyclase/phosphodiesterase. (632 aa)    
Predicted Functional Partners:
AEJ60715.1
Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: EAL domain; Response regulator receiver domain; GGDEF domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG2200 FOG: EAL domain; InterProIPR000014:IPR000160:IPR001789:IPR001633:IPR 013767; KEGG: sta:STHERM_c04670 hypothetical protein; PFAM: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; Signal transduction response regulator, receiver region; PAS fold; SMART: Diguanylate phosphodiesterase, predicted; Diguanylate cyclas [...]
 
 
0.956
AEJ60305.1
Diguanylate cyclase; PFAM: GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR000160; KEGG: sta:STHERM_c00180 hypothetical protein; PFAM: Diguanylate cyclase, predicted; SMART: Diguanylate cyclase, predicted; SPTR: Putative uncharacterized protein; TIGRFAM: Diguanylate cyclase, predicted.
 
 0.916
AEJ60351.1
Diguanylate cyclase; PFAM: GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR000160; KEGG: sta:STHERM_c00770 hypothetical protein; PFAM: Diguanylate cyclase, predicted; SMART: Diguanylate cyclase, predicted; SPTR: Diguanylate cyclase; TIGRFAM: Diguanylate cyclase, predicted.
 
 
 0.869
AEJ61090.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; Hpt domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR013656:IPR003661:IPR003594:IPR 001789:IPR008207; KEGG: sta:STHERM_c14170 two-component system, sensor histidine kinase; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; PAS fold-4; Signal transduction response regulator, receiver region; Signal transducti [...]
 
 0.869
AEJ60622.1
Diguanylate cyclase with PAS/PAC sensor; PFAM: GGDEF domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR000160:IPR000014:IPR013656; KEGG: sta:STHERM_c03690 GGDEF domain-containing protein; PFAM: Diguanylate cyclase, predicted; PAS fold-4; SMART: Diguanylate cyclase, predicted; PAS; SPTR: Diguanylate cyclase with PAS/PAC sensor; TIGRFAM: Diguanylate cyclase, predicted.
 
 0.854
AEJ61810.1
Diguanylate cyclase; PFAM: Cache domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain; COGs: COG2199 FOG: GGDEF domain; InterPro IPR000160; KEGG: sta:STHERM_c14110 hypothetical protein; PFAM: Diguanylate cyclase, predicted; SMART: Diguanylate cyclase, predicted; SPTR: Diguanylate cyclase; TIGRFAM: Diguanylate cyclase, predicted.
 
 0.853
AEJ60864.1
PAS/PAC sensor hybrid histidine kinase; PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR003661:IPR003594:IPR001789:IPR 013656:IPR013767; KEGG: sta:STHERM_c05640 hypothetical protein; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; PAS fold; PAS fold-4; Signal transduction response regulator, receiver region; SMAR [...]
 
 0.852
AEJ60861.1
Diguanylate cyclase; PFAM: GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain; COGs: COG2199 FOG: GGDEF domain; InterPro IPR000160; KEGG: sta:STHERM_c05610 hypothetical protein; PFAM: Diguanylate cyclase, predicted; SMART: Diguanylate cyclase, predicted; SPTR: Diguanylate cyclase; TIGRFAM: Diguanylate cyclase, predicted.
 
 0.851
AEJ61972.1
PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; Hpt domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR003661:IPR003594:IPR001789:IPR 008207:IPR013767:IPR013656; KEGG: sta:STHERM_c16510 autoinducer 2 sensor kinase/phosphatase LuxQ; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; PAS fold-4; PAS fold; Signal transduction response regulator, receiver region [...]
 
 0.850
AEJ60416.1
Integral membrane sensor hybrid histidine kinase; PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; COGs: COG0642 Signal transduction histidine kinase; InterPro IPR003661:IPR003594:IPR001789; KEGG: sta:STHERM_c01410 transcriptional regulatory protein; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; Signal transduction response regulator, receiver region; SMART: ATP-binding region, ATPase-like; Signal transduction histidine [...]
 
 0.847
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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