STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ61973.1PFAM: 3-oxo-5-alpha-steroid 4-dehydrogenase; InterPro IPR001104; KEGG: sta:STHERM_c16540 3-oxo-5-alpha-steroid 4-dehydrogenase family protein; PFAM: 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal; SPTR: 3-oxo-5-alpha-steroid 4-dehydrogenase. (245 aa)    
Predicted Functional Partners:
AEJ61974.1
PFAM: NAD dependent epimerase/dehydratase family; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: sta:STHERM_c16550 hypothetical protein; PFAM: NAD-dependent epimerase/dehydratase; SPTR: NAD-dependent epimerase/dehydratase.
 
     0.825
AEJ61975.1
Adenylyl cyclase CyaB; PFAM: CYTH domain; TIGRFAM: adenylyl cyclase CyaB, putative; COGs: COG1437 Adenylate cyclase class 2 (thermophilic); InterPro IPR008173:IPR008172; KEGG: sta:STHERM_c16560 hypothetical protein; PFAM: Adenylate cyclase; SPTR: Adenylyl cyclase CyaB; TIGRFAM: Adenylyl cyclase CyaB.
       0.773
purU
Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).
       0.773
AEJ61977.1
KEGG: sta:STHERM_c16580 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.550
crcB
CrcB-like protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family.
       0.550
AEJ61979.1
Protein of unknown function DUF190; PFAM: Uncharacterized ACR, COG1993; COGs: COG1993 conserved hypothetical protein; InterPro IPR003793; KEGG: sta:STHERM_c16600 CBS domain containing protein; PFAM: Protein of unknown function DUF190; SPTR: Putative uncharacterized protein.
       0.539
AEJ62326.1
RCC1 repeats protein; COGs: COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing protein; KEGG: sta:STHERM_c20190 RCC1 repeats protein; SPTR: Regulator of chromosome condensation RCC1.
  
     0.468
AEJ60733.1
Short-chain dehydrogenase/reductase SDR; PFAM: short chain dehydrogenase; COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002198; KEGG: sta:STHERM_c18110 retinol dehydrogenase 14; PFAM: Short-chain dehydrogenase/reductase SDR; SPTR: Short-chain dehydrogenase/reductase SDR.
 
     0.465
AEJ62217.1
Alpha/beta hydrolase fold containing protein; PFAM: Putative lysophospholipase; COGs: COG2267 Lysophospholipase; InterPro IPR000073; KEGG: sta:STHERM_c19130 hypothetical protein; PFAM: Alpha/beta hydrolase fold-1; SPTR: Alpha/beta hydrolase fold protein.
  
     0.462
AEJ61806.1
Short-chain dehydrogenase/reductase SDR; PFAM: short chain dehydrogenase; COGs: COG0300 Short-chain dehydrogenase of various substrate specificities; InterPro IPR002198; KEGG: sta:STHERM_c14070 dehydrogenase/reductase SDR family member 8 precursor; PFAM: Short-chain dehydrogenase/reductase SDR; SPTR: Short-chain dehydrogenase/reductase SDR; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
     0.410
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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