| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEJ61973.1 | AEJ61974.1 | Spith_1713 | Spith_1714 | PFAM: 3-oxo-5-alpha-steroid 4-dehydrogenase; InterPro IPR001104; KEGG: sta:STHERM_c16540 3-oxo-5-alpha-steroid 4-dehydrogenase family protein; PFAM: 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal; SPTR: 3-oxo-5-alpha-steroid 4-dehydrogenase. | PFAM: NAD dependent epimerase/dehydratase family; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: sta:STHERM_c16550 hypothetical protein; PFAM: NAD-dependent epimerase/dehydratase; SPTR: NAD-dependent epimerase/dehydratase. | 0.825 |
| AEJ61973.1 | AEJ61975.1 | Spith_1713 | Spith_1715 | PFAM: 3-oxo-5-alpha-steroid 4-dehydrogenase; InterPro IPR001104; KEGG: sta:STHERM_c16540 3-oxo-5-alpha-steroid 4-dehydrogenase family protein; PFAM: 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal; SPTR: 3-oxo-5-alpha-steroid 4-dehydrogenase. | Adenylyl cyclase CyaB; PFAM: CYTH domain; TIGRFAM: adenylyl cyclase CyaB, putative; COGs: COG1437 Adenylate cyclase class 2 (thermophilic); InterPro IPR008173:IPR008172; KEGG: sta:STHERM_c16560 hypothetical protein; PFAM: Adenylate cyclase; SPTR: Adenylyl cyclase CyaB; TIGRFAM: Adenylyl cyclase CyaB. | 0.773 |
| AEJ61973.1 | AEJ61977.1 | Spith_1713 | Spith_1717 | PFAM: 3-oxo-5-alpha-steroid 4-dehydrogenase; InterPro IPR001104; KEGG: sta:STHERM_c16540 3-oxo-5-alpha-steroid 4-dehydrogenase family protein; PFAM: 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal; SPTR: 3-oxo-5-alpha-steroid 4-dehydrogenase. | KEGG: sta:STHERM_c16580 hypothetical protein; SPTR: Putative uncharacterized protein. | 0.550 |
| AEJ61973.1 | AEJ61979.1 | Spith_1713 | Spith_1719 | PFAM: 3-oxo-5-alpha-steroid 4-dehydrogenase; InterPro IPR001104; KEGG: sta:STHERM_c16540 3-oxo-5-alpha-steroid 4-dehydrogenase family protein; PFAM: 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal; SPTR: 3-oxo-5-alpha-steroid 4-dehydrogenase. | Protein of unknown function DUF190; PFAM: Uncharacterized ACR, COG1993; COGs: COG1993 conserved hypothetical protein; InterPro IPR003793; KEGG: sta:STHERM_c16600 CBS domain containing protein; PFAM: Protein of unknown function DUF190; SPTR: Putative uncharacterized protein. | 0.539 |
| AEJ61973.1 | crcB | Spith_1713 | Spith_1718 | PFAM: 3-oxo-5-alpha-steroid 4-dehydrogenase; InterPro IPR001104; KEGG: sta:STHERM_c16540 3-oxo-5-alpha-steroid 4-dehydrogenase family protein; PFAM: 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal; SPTR: 3-oxo-5-alpha-steroid 4-dehydrogenase. | CrcB-like protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family. | 0.550 |
| AEJ61973.1 | purU | Spith_1713 | Spith_1716 | PFAM: 3-oxo-5-alpha-steroid 4-dehydrogenase; InterPro IPR001104; KEGG: sta:STHERM_c16540 3-oxo-5-alpha-steroid 4-dehydrogenase family protein; PFAM: 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal; SPTR: 3-oxo-5-alpha-steroid 4-dehydrogenase. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.773 |
| AEJ61974.1 | AEJ61973.1 | Spith_1714 | Spith_1713 | PFAM: NAD dependent epimerase/dehydratase family; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: sta:STHERM_c16550 hypothetical protein; PFAM: NAD-dependent epimerase/dehydratase; SPTR: NAD-dependent epimerase/dehydratase. | PFAM: 3-oxo-5-alpha-steroid 4-dehydrogenase; InterPro IPR001104; KEGG: sta:STHERM_c16540 3-oxo-5-alpha-steroid 4-dehydrogenase family protein; PFAM: 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal; SPTR: 3-oxo-5-alpha-steroid 4-dehydrogenase. | 0.825 |
| AEJ61974.1 | AEJ61975.1 | Spith_1714 | Spith_1715 | PFAM: NAD dependent epimerase/dehydratase family; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: sta:STHERM_c16550 hypothetical protein; PFAM: NAD-dependent epimerase/dehydratase; SPTR: NAD-dependent epimerase/dehydratase. | Adenylyl cyclase CyaB; PFAM: CYTH domain; TIGRFAM: adenylyl cyclase CyaB, putative; COGs: COG1437 Adenylate cyclase class 2 (thermophilic); InterPro IPR008173:IPR008172; KEGG: sta:STHERM_c16560 hypothetical protein; PFAM: Adenylate cyclase; SPTR: Adenylyl cyclase CyaB; TIGRFAM: Adenylyl cyclase CyaB. | 0.773 |
| AEJ61974.1 | AEJ61977.1 | Spith_1714 | Spith_1717 | PFAM: NAD dependent epimerase/dehydratase family; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: sta:STHERM_c16550 hypothetical protein; PFAM: NAD-dependent epimerase/dehydratase; SPTR: NAD-dependent epimerase/dehydratase. | KEGG: sta:STHERM_c16580 hypothetical protein; SPTR: Putative uncharacterized protein. | 0.550 |
| AEJ61974.1 | AEJ61979.1 | Spith_1714 | Spith_1719 | PFAM: NAD dependent epimerase/dehydratase family; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: sta:STHERM_c16550 hypothetical protein; PFAM: NAD-dependent epimerase/dehydratase; SPTR: NAD-dependent epimerase/dehydratase. | Protein of unknown function DUF190; PFAM: Uncharacterized ACR, COG1993; COGs: COG1993 conserved hypothetical protein; InterPro IPR003793; KEGG: sta:STHERM_c16600 CBS domain containing protein; PFAM: Protein of unknown function DUF190; SPTR: Putative uncharacterized protein. | 0.539 |
| AEJ61974.1 | crcB | Spith_1714 | Spith_1718 | PFAM: NAD dependent epimerase/dehydratase family; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: sta:STHERM_c16550 hypothetical protein; PFAM: NAD-dependent epimerase/dehydratase; SPTR: NAD-dependent epimerase/dehydratase. | CrcB-like protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family. | 0.550 |
| AEJ61974.1 | purU | Spith_1714 | Spith_1716 | PFAM: NAD dependent epimerase/dehydratase family; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: sta:STHERM_c16550 hypothetical protein; PFAM: NAD-dependent epimerase/dehydratase; SPTR: NAD-dependent epimerase/dehydratase. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.773 |
| AEJ61975.1 | AEJ61973.1 | Spith_1715 | Spith_1713 | Adenylyl cyclase CyaB; PFAM: CYTH domain; TIGRFAM: adenylyl cyclase CyaB, putative; COGs: COG1437 Adenylate cyclase class 2 (thermophilic); InterPro IPR008173:IPR008172; KEGG: sta:STHERM_c16560 hypothetical protein; PFAM: Adenylate cyclase; SPTR: Adenylyl cyclase CyaB; TIGRFAM: Adenylyl cyclase CyaB. | PFAM: 3-oxo-5-alpha-steroid 4-dehydrogenase; InterPro IPR001104; KEGG: sta:STHERM_c16540 3-oxo-5-alpha-steroid 4-dehydrogenase family protein; PFAM: 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal; SPTR: 3-oxo-5-alpha-steroid 4-dehydrogenase. | 0.773 |
| AEJ61975.1 | AEJ61974.1 | Spith_1715 | Spith_1714 | Adenylyl cyclase CyaB; PFAM: CYTH domain; TIGRFAM: adenylyl cyclase CyaB, putative; COGs: COG1437 Adenylate cyclase class 2 (thermophilic); InterPro IPR008173:IPR008172; KEGG: sta:STHERM_c16560 hypothetical protein; PFAM: Adenylate cyclase; SPTR: Adenylyl cyclase CyaB; TIGRFAM: Adenylyl cyclase CyaB. | PFAM: NAD dependent epimerase/dehydratase family; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: sta:STHERM_c16550 hypothetical protein; PFAM: NAD-dependent epimerase/dehydratase; SPTR: NAD-dependent epimerase/dehydratase. | 0.773 |
| AEJ61975.1 | AEJ61977.1 | Spith_1715 | Spith_1717 | Adenylyl cyclase CyaB; PFAM: CYTH domain; TIGRFAM: adenylyl cyclase CyaB, putative; COGs: COG1437 Adenylate cyclase class 2 (thermophilic); InterPro IPR008173:IPR008172; KEGG: sta:STHERM_c16560 hypothetical protein; PFAM: Adenylate cyclase; SPTR: Adenylyl cyclase CyaB; TIGRFAM: Adenylyl cyclase CyaB. | KEGG: sta:STHERM_c16580 hypothetical protein; SPTR: Putative uncharacterized protein. | 0.550 |
| AEJ61975.1 | AEJ61979.1 | Spith_1715 | Spith_1719 | Adenylyl cyclase CyaB; PFAM: CYTH domain; TIGRFAM: adenylyl cyclase CyaB, putative; COGs: COG1437 Adenylate cyclase class 2 (thermophilic); InterPro IPR008173:IPR008172; KEGG: sta:STHERM_c16560 hypothetical protein; PFAM: Adenylate cyclase; SPTR: Adenylyl cyclase CyaB; TIGRFAM: Adenylyl cyclase CyaB. | Protein of unknown function DUF190; PFAM: Uncharacterized ACR, COG1993; COGs: COG1993 conserved hypothetical protein; InterPro IPR003793; KEGG: sta:STHERM_c16600 CBS domain containing protein; PFAM: Protein of unknown function DUF190; SPTR: Putative uncharacterized protein. | 0.557 |
| AEJ61975.1 | crcB | Spith_1715 | Spith_1718 | Adenylyl cyclase CyaB; PFAM: CYTH domain; TIGRFAM: adenylyl cyclase CyaB, putative; COGs: COG1437 Adenylate cyclase class 2 (thermophilic); InterPro IPR008173:IPR008172; KEGG: sta:STHERM_c16560 hypothetical protein; PFAM: Adenylate cyclase; SPTR: Adenylyl cyclase CyaB; TIGRFAM: Adenylyl cyclase CyaB. | CrcB-like protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family. | 0.578 |
| AEJ61975.1 | purU | Spith_1715 | Spith_1716 | Adenylyl cyclase CyaB; PFAM: CYTH domain; TIGRFAM: adenylyl cyclase CyaB, putative; COGs: COG1437 Adenylate cyclase class 2 (thermophilic); InterPro IPR008173:IPR008172; KEGG: sta:STHERM_c16560 hypothetical protein; PFAM: Adenylate cyclase; SPTR: Adenylyl cyclase CyaB; TIGRFAM: Adenylyl cyclase CyaB. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.784 |
| AEJ61977.1 | AEJ61973.1 | Spith_1717 | Spith_1713 | KEGG: sta:STHERM_c16580 hypothetical protein; SPTR: Putative uncharacterized protein. | PFAM: 3-oxo-5-alpha-steroid 4-dehydrogenase; InterPro IPR001104; KEGG: sta:STHERM_c16540 3-oxo-5-alpha-steroid 4-dehydrogenase family protein; PFAM: 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal; SPTR: 3-oxo-5-alpha-steroid 4-dehydrogenase. | 0.550 |
| AEJ61977.1 | AEJ61974.1 | Spith_1717 | Spith_1714 | KEGG: sta:STHERM_c16580 hypothetical protein; SPTR: Putative uncharacterized protein. | PFAM: NAD dependent epimerase/dehydratase family; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: sta:STHERM_c16550 hypothetical protein; PFAM: NAD-dependent epimerase/dehydratase; SPTR: NAD-dependent epimerase/dehydratase. | 0.550 |