STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
metE5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (755 aa)    
Predicted Functional Partners:
metK
S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 0.977
AEJ60486.1
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.976
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
 
 0.968
AEJ62459.1
PFAM: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase, prokaryotic form; COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR004620:IPR003171; KEGG: sta:STHERM_c21610 5,10-methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; SPTR: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase.
 
 
 0.933
AEJ61142.1
PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase; COGs: COG2873 O-acetylhomoserine sulfhydrylase; InterPro IPR006235:IPR000277; KEGG: sta:STHERM_c12890 O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; SPTR: O-acetylhomoserine sulfhydrolase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase.
  
 
 0.919
AEJ61946.1
PFAM: Cys/Met metabolism PLP-dependent enzyme; COGs: COG2873 O-acetylhomoserine sulfhydrylase; InterPro IPR000277; KEGG: sta:STHERM_c16260 O-acetylhomoserineaminocarboxypropyltransferase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; SPTR: Cys/Met metabolism pyridoxal-phosphate-dependent protein.
  
 
 0.919
metG
Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
    
 0.918
AEJ60465.1
PFAM: Homoserine dehydrogenase, NAD binding domain; Homoserine dehydrogenase; ACT domain; COGs: COG0460 Homoserine dehydrogenase; InterPro IPR005106:IPR001342:IPR002912; KEGG: sta:STHERM_c01940 homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT; SPTR: Homoserine dehydrogenase.
  
 
 0.869
AEJ60340.1
Aspartate kinase; PFAM: ACT domain; Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; COGs: COG0527 Aspartokinase; InterPro IPR001048:IPR002912:IPR001341; KEGG: sta:STHERM_c00530 aspartate kinase; PFAM: Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; SPTR: Aspartokinase; TIGRFAM: Aspartate kinase region.
  
 
 0.854
AEJ62480.1
Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; COGs: COG0560 Phosphoserine phosphatase; InterPro IPR011863:IPR005834; KEGG: sta:STHERM_c21790 hypothetical protein; PFAM: Haloacid dehalogenase-like hydrolase; SPTR: Phosphoserine:homoserine phosphotransferase; phosphoserine phosphatase; TIGRFAM: Phosphoserine phosphatase/homoserine phosphotransferas [...]
    
 0.826
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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