STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
argJArginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (429 aa)    
Predicted Functional Partners:
AEJ62062.1
Amino-acid N-acetyltransferase; PFAM: Acetyltransferase (GNAT) family; Amino acid kinase family; TIGRFAM: amino-acid N-acetyltransferase; COGs: COG0548 Acetylglutamate kinase; InterPro IPR010167:IPR001048:IPR000182; KEGG: sta:STHERM_c17320 amino acid acetyltransferase; PFAM: GCN5-related N-acetyltransferase; Aspartate/glutamate/uridylate kinase; SPTR: Amino-acid N-acetyltransferase; TIGRFAM: Amino-acid N-acetyltransferase (ArgA); Belongs to the acetyltransferase family.
 
 0.997
argB
Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.
 
 0.997
AEJ62312.1
PFAM: Aminotransferase class-III; TIGRFAM: acetylornithine and succinylornithine aminotransferases; COGs: COG4992 Ornithine/acetylornithine aminotransferase; HAMAP: Acetylornithine/succinyldiaminopimelate aminotransferase; InterPro IPR005814:IPR004636; KEGG: sta:STHERM_c20050 acetylornithine aminotransferase; PFAM: Aminotransferase class-III; SPTR: Acetylornithine and succinylornithine aminotransferase; TIGRFAM: Acetylornithine/succinylornithine aminotransferase.
 
 
 0.995
AEJ60887.1
Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
 
 
 0.991
argC
N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
 
  
 0.976
argG
PFAM: Arginosuccinate synthase; TIGRFAM: argininosuccinate synthase; COGs: COG0137 Argininosuccinate synthase; HAMAP: Argininosuccinate synthase; InterPro IPR001518; KEGG: sta:STHERM_c20060 argininosuccinate synthase; PFAM: Argininosuccinate synthase; SPTR: Argininosuccinate synthase; TIGRFAM: Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
 
  
 0.913
AEJ61068.1
PFAM: Aminotransferase class I and II; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004839; KEGG: sta:STHERM_c14400 aspartate aminotransferase; PFAM: Aminotransferase, class I/II; SPTR: Aminotransferase class I and II.
    
 0.911
argR
Arginine repressor, ArgR; Regulates arginine biosynthesis genes.
  
  
 0.891
argH
PFAM: Lyase; TIGRFAM: argininosuccinate lyase; COGs: COG0165 Argininosuccinate lyase; HAMAP: Argininosuccinate lyase; InterPro IPR009049:IPR000362; KEGG: sta:STHERM_c13370 argininosuccinate lyase; PFAM: Fumarate lyase; SPTR: Argininosuccinate lyase; TIGRFAM: Argininosuccinate lyase.
  
  
 0.885
AEJ61994.1
PFAM: Smr domain; COGs: COG2840 conserved hypothetical protein; InterPro IPR002625; KEGG: sta:STHERM_c16740 hypothetical protein; PFAM: Smr protein/MutS2 C-terminal; SMART: Smr protein/MutS2 C-terminal; SPTR: Smr protein/MutS2.
       0.696
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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