STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ62037.1Pentapeptide repeat protein; COGs: COG1357 Uncharacterized low-complexity protein; InterPro IPR001646; KEGG: sta:STHERM_c17050 pentapeptide protein; PFAM: Pentapeptide repeat; SPTR: Pentapeptide repeat protein. (202 aa)    
Predicted Functional Partners:
AEJ62038.1
PFAM: Metallo-beta-lactamase superfamily; COGs: COG0491 Zn-dependent hydrolase including glyoxylase; KEGG: sta:STHERM_c17070 beta lactamase like protein; SPTR: Putative uncharacterized protein.
     
 0.819
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.717
AEJ62036.1
KEGG: sta:STHERM_c17060 hypothetical protein; SPTR: Putative uncharacterized protein; manually curated.
 
     0.685
AEJ62146.1
Lytic transglycosylase catalytic; PFAM: Transglycosylase SLT domain; LysM domain; InterPro IPR008258:IPR018392:IPR002482; KEGG: sta:STHERM_c18450 transglycosylase, SLT family; PFAM: Lytic transglycosylase-like, catalytic; Peptidoglycan-binding lysin domain; SMART: Peptidoglycan-binding Lysin subgroup; SPTR: Lytic transglycosylase catalytic.
   
 
 0.675
rsgA-2
Sigma 54 interacting domain protein; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
  
    0.635
murI
Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.
       0.609
AEJ61757.1
PFAM: Protein of unknown function (DUF2807); KEGG: sta:STHERM_c13580 hypothetical protein; SPTR: Putative uncharacterized protein.
   
   0.601
AEJ61188.1
KEGG: sta:STHERM_c08890 hypothetical protein; SPTR: Putative uncharacterized protein.
  
     0.597
AEJ61626.1
Protein of unknown function YGGT; PFAM: YGGT family; InterPro IPR003425; KEGG: sta:STHERM_c08080 hypothetical protein; PFAM: Protein of unknown function YGGT; SPTR: Putative uncharacterized protein.
 
     0.554
AEJ60544.1
PFAM: Uncharacterised protein family (UPF0158); KEGG: sta:STHERM_c02740 hypothetical protein; SPTR: Putative uncharacterized protein.
  
     0.521
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.