STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ62076.1PFAM: HEPN domain; InterPro IPR007842; KEGG: sta:STHERM_c17460 HEPN domain-containing protein; PFAM: HEPN; SMART: HEPN; SPTR: HEPN domain protein. (138 aa)    
Predicted Functional Partners:
AEJ62075.1
DNA polymerase beta domain protein region; PFAM: Nucleotidyltransferase domain; InterPro IPR002934; KEGG: sta:STHERM_c17450 nucleotidyltransferase domain-containing protein; PFAM: Nucleotidyltransferase; SPTR: DNA polymerase beta domain protein region.
 
 
   0.950
AEJ61864.1
PFAM: HEPN domain; COGs: COG2250 conserved hypothetical protein related to C-terminal domain of eukaryotic chaperone SACSIN; InterPro IPR007842; KEGG: HEPN domain protein; PFAM: HEPN; SMART: HEPN; SPTR: Putative uncharacterized protein; manually curated.
  
     0.742
AEJ61865.1
DNA polymerase subunit beta; PFAM: Nucleotidyltransferase domain; KEGG: rca:Rcas_3922 DNA polymerase subunit beta; SPTR: DNA polymerase beta subunit.
 
 
   0.520
AEJ62074.1
HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; 2-phosphoglycolate phosphatase, prokaryotic; COGs: COG0546 phosphatase; InterPro IPR006402:IPR006439:IPR005834; KEGG: sta:STHERM_c17440 hydrolase; PFAM: Haloacid dehalogenase-like hydrolase; SPTR: HAD-superfamily hydrolase, subfamily IA, variant 3; TIGRFAM: HAD-superfamily hydrolase, subf [...]
       0.487
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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