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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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gene co-occurrence
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[Homology]
Score
truAtRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (248 aa)    
Predicted Functional Partners:
priA
Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily.
 
   
 0.857
rpoA
DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
 
  
 0.839
AEJ62138.1
Dihydropteroate synthase; PFAM: Pterin binding enzyme; TIGRFAM: dihydropteroate synthase; COGs: COG0294 Dihydropteroate synthase; InterPro IPR000489:IPR006390; KEGG: sta:STHERM_c18380 dihydropteroate synthase; PFAM: Dihydropteroate synthase, DHPS; SPTR: Dihydropteroate synthase; TIGRFAM: Dihydropteroate synthase.
  
  
 0.812
AEJ62132.1
Phage SPO1 DNA polymerase-related protein; PFAM: Uracil DNA glycosylase superfamily; TIGRFAM: uracil-DNA glycosylase, family 4; COGs: COG1573 Uracil-DNA glycosylase; InterPro IPR005122:IPR005273; KEGG: sta:STHERM_c18320 hypothetical protein; PFAM: Uracil-DNA glycosylase-like; SPTR: Phage SPO1 DNA polymerase-related protein; TIGRFAM: Phage SPO1 DNA polymerase-related protein.
  
    0.811
AEJ62134.1
Protein of unknown function DUF2225; PFAM: Uncharacterized protein conserved in bacteria (DUF2225); COGs: COG1655 conserved hypothetical protein; InterPro IPR018708; KEGG: sta:STHERM_c18340 hypothetical protein; PFAM: Protein of unknown function DUF2225; SPTR: Putative uncharacterized protein.
       0.806
acpS
Holo-(acyl-carrier-protein) synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family.
       0.806
AEJ62136.1
PFAM: YbbR-like protein; COGs: COG4856 conserved hypothetical protein; InterPro IPR012505; KEGG: sta:STHERM_c18360 membrane associated protein; PFAM: YbbR-like; SPTR: YbbR family protein.
       0.806
dacA
Conserved hypothetical protein CHP00159; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
       0.806
rplQ
PFAM: Ribosomal protein L17; TIGRFAM: ribosomal protein L17; COGs: COG0203 Ribosomal protein L17; HAMAP: 50S ribosomal protein L17; InterPro IPR000456; KEGG: sta:STHERM_c05220 50S ribosomal protein L17; PFAM: Ribosomal protein L17; SPTR: 50S ribosomal protein L17; TIGRFAM: Ribosomal protein L17.
  
  
 0.773
truB
tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
  
 
 0.755
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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