Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEJ62144.1Isocitrate dehydrogenase, NADP-dependent; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent, prokaryotic type; COGs: COG0538 Isocitrate dehydrogenase; InterPro IPR001804:IPR004439; KEGG: sta:STHERM_c18430 isocitrate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; SPTR: Isocitrate dehydrogenase (NADP); TIGRFAM: Isocitrate dehydrogenase NADP-dependent, prokaryotic. (402 aa)    
Predicted Functional Partners:
AEJ62372.1
Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
 
 0.994
AEJ61466.1
PFAM: Citrate synthase; COGs: COG0372 Citrate synthase; InterPro IPR002020; KEGG: sta:STHERM_c11610 hypothetical protein; PFAM: Citrate synthase-like; SPTR: Citrate synthase.
  
 0.945
AEJ61321.1
PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II; COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: sta:STHERM_c10240 glutamate synthase; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; SPTR: Glutamate synthase (NADH) large subunit.
    
 0.883
AEJ61297.1
PFAM: Lyase; Adenylosuccinate lyase C-terminus; COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362; KEGG: sta:STHERM_c10000 adenylosuccinate lyase; PFAM: Fumarate lyase; SPTR: Fumarate lyase.
  
 
 0.831
AEJ61068.1
PFAM: Aminotransferase class I and II; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004839; KEGG: sta:STHERM_c14400 aspartate aminotransferase; PFAM: Aminotransferase, class I/II; SPTR: Aminotransferase class I and II.
   
 
 0.826
AEJ60644.1
PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: 3-isopropylmalate dehydrogenase; COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR001804; KEGG: sta:STHERM_c03940 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; SPTR: 3-isopropylmalate dehydrogenase.
 
0.823
AEJ61336.1
L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate.
     
 0.816
AEJ60768.1
PFAM: Lyase; COGs: COG1027 Aspartate ammonia-lyase; InterPro IPR000362; KEGG: sta:STHERM_c17980 aspartate ammonia-lyase AspA; PFAM: Fumarate lyase; SPTR: Fumarate lyase.
     
 0.815
argH
PFAM: Lyase; TIGRFAM: argininosuccinate lyase; COGs: COG0165 Argininosuccinate lyase; HAMAP: Argininosuccinate lyase; InterPro IPR009049:IPR000362; KEGG: sta:STHERM_c13370 argininosuccinate lyase; PFAM: Fumarate lyase; SPTR: Argininosuccinate lyase; TIGRFAM: Argininosuccinate lyase.
   
 
 0.815
AEJ61322.1
Glutamate synthase, NADH/NADPH, small subunit; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthases, NADH/NADPH, small subunit; COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR013027:IPR006005; KEGG: sta:STHERM_c10250 hypothetical protein; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: Glutamate synthase (NADH) small subunit; TIGRFAM: Glutamate synthase, NADH/NADPH, small subunit 1.
     
 0.808
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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