STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ62174.1HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; COGs: COG1011 hydrolase (HAD superfamily); InterPro IPR005834:IPR006439; KEGG: sta:STHERM_c18720 hydrolase of the HAD superfamily; PFAM: Haloacid dehalogenase-like hydrolase; SPTR: HAD-superfamily hydrolase, subfamily IA, variant 1; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 1. (220 aa)    
Predicted Functional Partners:
AEJ62173.1
KEGG: sta:STHERM_c18710 cytoskeletal protein; SPTR: Putative uncharacterized protein.
 
     0.802
grpE
Protein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
       0.558
dnaJ
Chaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
   
   0.521
dnaK
Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
       0.518
AEJ62176.1
Conserved hypothetical protein CHP00268; PFAM: NAD synthase; TIGRFAM: TIGR00268 family protein; COGs: COG1606 ATP-utilizing protein of the PP-loop superfamily; InterPro IPR001962:IPR005232; KEGG: sta:STHERM_c18740 hypothetical protein; PFAM: Asparagine synthase; SPTR: Asparagine synthase; TIGRFAM: Conserved hypothetical protein CHP00268.
       0.517
AEJ62175.1
1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase; PFAM: AIR carboxylase; COGs: COG1691 NCAIR mutase (PurE)-related protein; InterPro IPR000031; KEGG: sta:STHERM_c18730 hypothetical protein; PFAM: 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; SPTR: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase.
       0.509
AEJ62177.1
PFAM: Protein of unknown function DUF111; TIGRFAM: TIGR00299 family protein; COGs: COG1641 conserved hypothetical protein; HAMAP: UPF0272 protein; InterPro IPR002822; KEGG: dma:DMR_16560 hypothetical protein; PFAM: Protein of unknown function DUF111; SPTR: Putative uncharacterized protein; TIGRFAM: Protein of unknown function DUF111; Belongs to the LarC family.
       0.509
AEJ62522.1
Glycoside hydrolase family 37; PFAM: Trehalase; COGs: COG1626 Neutral trehalase; InterPro IPR001661; KEGG: sta:STHERM_c22220 hypothetical protein; PFAM: Glycoside hydrolase, family 37; SPTR: Glycoside hydrolase family 37.
  
    0.424
AEJ60315.1
Phosphatidate cytidylyltransferase; COGs: COG0170 Dolichol kinase; InterPro IPR000374; KEGG: sta:STHERM_c00280 phosphatidate cytidylyltransferase; PFAM: Phosphatidate cytidylyltransferase; SPTR: Phosphatidate cytidylyltransferase.
  
     0.400
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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