STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ62231.1PFAM: Rhomboid family; InterPro IPR002610; KEGG: sta:STHERM_c19270 rhomboid-like protein; PFAM: Peptidase S54, rhomboid; SPTR: Rhomboid family protein. (187 aa)    
Predicted Functional Partners:
prfA
Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
     
 0.787
prmC
protein-(glutamine-N5) methyltransferase, release factor-specific; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
     
 0.786
AEJ62234.1
(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
  
    0.785
AEJ62230.1
Exodeoxyribonuclease III Xth; PFAM: Endonuclease/Exonuclease/phosphatase family; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III (xth); COGs: COG0708 Exonuclease III; InterPro IPR005135:IPR004808:IPR000097; KEGG: sta:STHERM_c19260 hypothetical protein; PFAM: Endonuclease/exonuclease/phosphatase; SPTR: Exodeoxyribonuclease III Xth; TIGRFAM: Exodeoxyribonuclease III xth; AP endonuclease, family 1.
       0.684
AEJ61262.1
Cell wall hydrolase/autolysin; PFAM: N-acetylmuramoyl-L-alanine amidase; COGs: COG0860 N-acetylmuramoyl-L-alanine amidase; InterPro IPR002508; KEGG: sta:STHERM_c09650 hypothetical protein; PFAM: Cell wall hydrolase/autolysin, catalytic; SMART: Cell wall hydrolase/autolysin, catalytic; SPTR: Cell wall hydrolase/autolysin.
  
   0.618
tpx
Thiol peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily.
       0.562
AEJ62229.1
PFAM: ABC transporter; COGs: COG0488 ATPase components of ABC transporter with duplicated ATPase domains; InterPro IPR003439:IPR003593; KEGG: sta:STHERM_c19250 transporter; PFAM: ABC transporter-like; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related protein.
  
    0.541
AEJ62228.1
PFAM: Bacterial SH3 domain; InterPro IPR013247; KEGG: sta:STHERM_c19240 lipoprotein; PFAM: SH3, type 3; SPTR: SH3 type 3 domain protein.
       0.538
AEJ60430.1
Peptidoglycan-binding lysin domain-containing protein; PFAM: LysM domain; InterPro IPR018392:IPR002482; KEGG: sta:STHERM_c01550 hypothetical protein; PFAM: Peptidoglycan-binding lysin domain; SMART: Peptidoglycan-binding Lysin subgroup; SPTR: Peptidoglycan-binding lysin domain.
 
  
 0.531
AEJ60495.1
PFAM: 5-formyltetrahydrofolate cyclo-ligase family; TIGRFAM: 5,10-methenyltetrahydrofolate synthetase; COGs: COG0212 5-formyltetrahydrofolate cyclo-ligase; InterPro IPR002698; KEGG: sta:STHERM_c02250 5-formyltetrahydrofolatecyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; SPTR: 5-formyltetrahydrofolate cyclo-ligase; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase.
  
    0.485
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.