STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
AEJ62244.1RNA methyltransferase, TrmH family, group 2; Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily. (154 aa)    
Predicted Functional Partners:
AEJ62243.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterPro IPR001789:IPR003661:IPR003594; KEGG: sta:STHERM_c19390 histidine kinase; PFAM: Signal transduction response regulator, receiver region; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; ATP-binding region, ATPase-like; SMART: Signal transduction response regulator, receiver region; Signal transduction h [...]
       0.777
proC
Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
       0.722
AEJ62071.1
Protein of unknown function DUF2166; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; COGs: COG4696 conserved hypothetical protein; InterPro IPR019229; KEGG: sta:STHERM_c17410 hypothetical protein; PFAM: Protein of unknown function DUF2166; SPTR: Putative uncharacterized protein.
   
    0.631
serS
Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec).
       0.587
AEJ62242.1
PFAM: Histidine kinase; 5TMR of 5TMR-LYT; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG3920 Signal transduction histidine kinase; InterProIPR011620:IPR013767:IPR011495:IPR003594:IPR 000014:IPR001610; KEGG: sta:STHERM_c19380 hypothetical protein; PFAM: Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor region; PAS fold; Signal transduction histidine kinase, 5TM receptor LytS, transmembrane region; ATP-binding region, ATPase-like; SMART: PAS; PAC motif; ATP-binding region, ATPase-like; SPTR: Signal [...]
     
 0.571
AEJ62247.1
N-acetylneuraminic acid synthase domain-containing protein; PFAM: SAF domain; NeuB family; COGs: COG2089 Sialic acid synthase; InterPro IPR013132:IPR013974; KEGG: sta:STHERM_c19430 NeuB family protein; PFAM: N-acetylneuraminic acid synthase, N-terminal; SAF domain; SPTR: N-acetylneuraminic acid synthase domain.
       0.475
tig
Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily.
 
    0.429
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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