STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (265 aa)    
Predicted Functional Partners:
proB
Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
 
 
 0.833
proA
Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.
 
 
 0.802
AEJ62244.1
RNA methyltransferase, TrmH family, group 2; Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
       0.728
AEJ62243.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterPro IPR001789:IPR003661:IPR003594; KEGG: sta:STHERM_c19390 histidine kinase; PFAM: Signal transduction response regulator, receiver region; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; ATP-binding region, ATPase-like; SMART: Signal transduction response regulator, receiver region; Signal transduction h [...]
     
 0.690
serS
Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec).
       0.656
AEJ62247.1
N-acetylneuraminic acid synthase domain-containing protein; PFAM: SAF domain; NeuB family; COGs: COG2089 Sialic acid synthase; InterPro IPR013132:IPR013974; KEGG: sta:STHERM_c19430 NeuB family protein; PFAM: N-acetylneuraminic acid synthase, N-terminal; SAF domain; SPTR: N-acetylneuraminic acid synthase domain.
  
    0.545
AEJ62242.1
PFAM: Histidine kinase; 5TMR of 5TMR-LYT; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG3920 Signal transduction histidine kinase; InterProIPR011620:IPR013767:IPR011495:IPR003594:IPR 000014:IPR001610; KEGG: sta:STHERM_c19380 hypothetical protein; PFAM: Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor region; PAS fold; Signal transduction histidine kinase, 5TM receptor LytS, transmembrane region; ATP-binding region, ATPase-like; SMART: PAS; PAC motif; ATP-binding region, ATPase-like; SPTR: Signal [...]
     
 0.500
AEJ62280.1
Transketolase domain-containing protein; PFAM: Dehydrogenase E1 component; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; Transketolase, C-terminal domain; Biotin-requiring enzyme; Transketolase, pyrimidine binding domain; TIGRFAM: 3-oxoacyl-(acyl-carrier-protein) synthase III; COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; InterProIPR001017:IPR005475:IPR005476:IPR000089:IPR 013751:IPR013747; KEGG: sta:STHERM_c19760 hypothetical protein; PFAM: Tr [...]
  
 
 0.453
AEJ62248.1
PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; TIGRFAM: PAS domain S-box; COGs: COG3920 Signal transduction histidine kinase; InterPro IPR011495:IPR003594:IPR000014; KEGG: sta:STHERM_c19440 sensory box histidine kinase; PFAM: Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor region; ATP-binding region, ATPase-like; SPTR: Signal transduction histidine kinase; TIGRFAM: PAS.
       0.443
AEJ62062.1
Amino-acid N-acetyltransferase; PFAM: Acetyltransferase (GNAT) family; Amino acid kinase family; TIGRFAM: amino-acid N-acetyltransferase; COGs: COG0548 Acetylglutamate kinase; InterPro IPR010167:IPR001048:IPR000182; KEGG: sta:STHERM_c17320 amino acid acetyltransferase; PFAM: GCN5-related N-acetyltransferase; Aspartate/glutamate/uridylate kinase; SPTR: Amino-acid N-acetyltransferase; TIGRFAM: Amino-acid N-acetyltransferase (ArgA); Belongs to the acetyltransferase family.
     
 0.430
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.