STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ62251.1Metallophosphoesterase; PFAM: Calcineurin-like phosphoesterase; COGs: COG1409 phosphohydrolase; InterPro IPR004843; KEGG: sta:STHERM_c19460 hypothetical protein; PFAM: Metallophosphoesterase; SPTR: Metallophosphoesterase. (242 aa)    
Predicted Functional Partners:
AEJ61394.1
Adenylate/guanylate cyclase with Chase sensor; PFAM: Adenylate and Guanylate cyclase catalytic domain; CHASE2 domain; COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterPro IPR007890:IPR001054; KEGG: sta:STHERM_c10940 hypothetical protein; PFAM: Adenylyl cyclase class-3/4/guanylyl cyclase; CHASE2; SMART: Adenylyl cyclase class-3/4/guanylyl cyclase; SPTR: Adenylate/guanylate cyclase with Chase sensor.
     
 0.919
AEJ60381.1
Adenylate/guanylate cyclase with TPR repeats; PFAM: Adenylate and Guanylate cyclase catalytic domain; HAMP domain; COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterPro IPR003660:IPR001054:IPR013105; KEGG: sta:STHERM_c01070 adenylate cyclase; PFAM: Adenylyl cyclase class-3/4/guanylyl cyclase; HAMP linker domain; Tetratricopeptide TPR2; SMART: Adenylyl cyclase class-3/4/guanylyl cyclase; HAMP linker domain; SPTR: Adenylate/guanylate cyclase with integral membrane sensor.
     
 0.913
AEJ61975.1
Adenylyl cyclase CyaB; PFAM: CYTH domain; TIGRFAM: adenylyl cyclase CyaB, putative; COGs: COG1437 Adenylate cyclase class 2 (thermophilic); InterPro IPR008173:IPR008172; KEGG: sta:STHERM_c16560 hypothetical protein; PFAM: Adenylate cyclase; SPTR: Adenylyl cyclase CyaB; TIGRFAM: Adenylyl cyclase CyaB.
     
 0.911
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
     
 0.904
AEJ61517.1
Adenylate/guanylate cyclase with integral membrane sensor; PFAM: Adenylate and Guanylate cyclase catalytic domain; HAMP domain; COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterPro IPR003660:IPR001054; KEGG: sta:STHERM_c12100 adenylate/guanylate cyclase; PFAM: Adenylyl cyclase class-3/4/guanylyl cyclase; HAMP linker domain; SMART: HAMP linker domain; Adenylyl cyclase class-3/4/guanylyl cyclase; SPTR: Adenylate/guanylate cyclase with integral membrane sensor.
     
 0.903
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  
 
 0.903
AEJ62073.1
PFAM: Adenylate and Guanylate cyclase catalytic domain; 7TM diverse intracellular signalling; 7TMR-DISM extracellular 2; COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterPro IPR001054; KEGG: sta:STHERM_c17430 adenylate cyclase / guanylate cyclase; PFAM: Adenylyl cyclase class-3/4/guanylyl cyclase; SMART: Adenylyl cyclase class-3/4/guanylyl cyclase; SPTR: Adenylate/guanylate cyclase; manually curated.
     
 0.903
AEJ62178.1
Diverse 7TM receptor transmembrane region; PFAM: 7TM diverse intracellular signalling; InterPro IPR011623; KEGG: sta:STHERM_c18750 hypothetical protein; PFAM: Diverse 7TM receptor, transmembrane region; SPTR: Diverse 7TM receptor transmembrane region.
     
 0.903
surE
Multifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
  0.900
AEJ61297.1
PFAM: Lyase; Adenylosuccinate lyase C-terminus; COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362; KEGG: sta:STHERM_c10000 adenylosuccinate lyase; PFAM: Fumarate lyase; SPTR: Fumarate lyase.
     
  0.900
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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