STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
nthHhH-GPD family protein; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (238 aa)    
Predicted Functional Partners:
AEJ62230.1
Exodeoxyribonuclease III Xth; PFAM: Endonuclease/Exonuclease/phosphatase family; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III (xth); COGs: COG0708 Exonuclease III; InterPro IPR005135:IPR004808:IPR000097; KEGG: sta:STHERM_c19260 hypothetical protein; PFAM: Endonuclease/exonuclease/phosphatase; SPTR: Exodeoxyribonuclease III Xth; TIGRFAM: Exodeoxyribonuclease III xth; AP endonuclease, family 1.
 
 0.958
rnfE
Electron transport complex, RnfABCDGE type, E subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
 
  
 0.715
AEJ62176.1
Conserved hypothetical protein CHP00268; PFAM: NAD synthase; TIGRFAM: TIGR00268 family protein; COGs: COG1606 ATP-utilizing protein of the PP-loop superfamily; InterPro IPR001962:IPR005232; KEGG: sta:STHERM_c18740 hypothetical protein; PFAM: Asparagine synthase; SPTR: Asparagine synthase; TIGRFAM: Conserved hypothetical protein CHP00268.
 
    0.705
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 
 0.576
AEJ62365.1
PFAM: Cellulase (glycosyl hydrolase family 5); COGs: COG2730 Endoglucanase; InterPro IPR001547; KEGG: sta:STHERM_c20620 cellulase, glycosyl hydrolase family 5, TPS linker, domain X; PFAM: Glycoside hydrolase, family 5; SPTR: Glycoside hydrolase family 5; Belongs to the glycosyl hydrolase 5 (cellulase A) family.
       0.529
AEJ60745.1
PFAM: Rnf-Nqr subunit, membrane protein; COGs: COG4660 NADH:ubiquinone oxidoreductase subunit RnfE; KEGG: sta:STHERM_c04440 hypothetical protein; SPTR: Electron transport complex RsxE subunit; Belongs to the NqrDE/RnfAE family.
  
  
 0.503
rnfB
Electron transport complex, RnfABCDGE type, B subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
  
  
 0.483
rnfG
FMN-binding domain protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the RnfG family.
  
  
 0.432
rnfG-2
Electron transport complex, RnfABCDGE type, G subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the RnfG family.
  
  
 0.432
AEJ62364.1
Glycoside hydrolase family 9; PFAM: Cellulose binding domain; Glycosyl hydrolase family 9; InterPro IPR001701:IPR001956; KEGG: sta:STHERM_c20630 glycoside hydrolase family 9, CBM3, linker, domain X; PFAM: Glycoside hydrolase, family 9; Bacterial type 3a, cellulose-binding; SPTR: Cellulase.
       0.430
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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