STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEJ62391.1Aromatic amino acid beta-eliminating lyase/threonine aldolase; PFAM: Beta-eliminating lyase; COGs: COG2008 Threonine aldolase; InterPro IPR001597; KEGG: sta:STHERM_c20910 hypothetical protein; PFAM: Aromatic amino acid beta-eliminating lyase/threonine aldolase; SPTR: Aromatic amino acid beta-eliminating lyase/threonine aldolase. (338 aa)    
Predicted Functional Partners:
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
   
 0.938
AEJ60341.1
Threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase; COGs: COG0498 Threonine synthase; InterPro IPR001926:IPR004450; KEGG: sta:STHERM_c00540 threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; SPTR: Threonine synthase; TIGRFAM: Threonine synthase.
   
 0.926
AEJ62389.1
Aconitate hydratase domain-containing protein; PFAM: Aconitase C-terminal domain; TIGRFAM: 3-isopropylmalate dehydratase, small subunit; COGs: COG0066 3-isopropylmalate dehydratase small subunit; InterPro IPR000573; KEGG: sta:STHERM_c20890 hypothetical protein; PFAM: Aconitase A/isopropylmalate dehydratase small subunit, swivel; SPTR: 3-isopropylmalate dehydratase, small subunit; Belongs to the LeuD family.
       0.538
AEJ62390.1
PFAM: Aconitase family (aconitate hydratase); TIGRFAM: 3-isopropylmalate dehydratase, large subunit; homoaconitate hydratase family protein; COGs: COG0065 3-isopropylmalate dehydratase large subunit; InterPro IPR011826:IPR006251:IPR001030; KEGG: sta:STHERM_c20900 3-isopropylmalate dehydratase large subunit; PFAM: Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; SPTR: 3-isopropylmalate dehydratase, large subunit; TIGRFAM: Homoaconitase/3-isopropylmalate dehydratase, large subunit, subgroup; Homoaconitase/3-isopropylmalate dehydratase, large subunit, prokaryotic; [...]
       0.538
AEJ61321.1
PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II; COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: sta:STHERM_c10240 glutamate synthase; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; SPTR: Glutamate synthase (NADH) large subunit.
     
 0.409
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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