STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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AEJ62414.1Putative signal transduction histidine kinase; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; COGs: COG3920 Signal transduction histidine kinase; InterPro IPR003594; KEGG: sta:STHERM_c21140 signal transduction histidine kinase; PFAM: ATP-binding region, ATPase-like; SMART: ATP-binding region, ATPase-like; SPTR: Putative signal transduction histidine kinase. (211 aa)    
Predicted Functional Partners:
AEJ60303.1
PFAM: Response regulator receiver domain; PAS fold; COGs: COG0784 FOG: CheY-like receiver; InterPro IPR001789; KEGG: sta:STHERM_c00160 transcriptional regulatory protein; PFAM: Signal transduction response regulator, receiver region; SMART: Signal transduction response regulator, receiver region; SPTR: Response regulator receiver protein.
 
 
 
 0.836
AEJ61016.1
PFAM: Response regulator receiver domain; InterPro IPR001789; KEGG: sta:STHERM_c14860 hypothetical protein; PFAM: Signal transduction response regulator, receiver region; SMART: Signal transduction response regulator, receiver region; SPTR: Response regulator receiver.
 
   
 0.780
AEJ62413.1
PFAM: Radical SAM superfamily; B12 binding domain; COGs: COG1032 Fe-S oxidoreductase; InterPro IPR007197:IPR006638; KEGG: sta:STHERM_c21130 methyltransferase; PFAM: Radical SAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: Radical SAM domain protein.
       0.773
AEJ61423.1
PFAM: Histidine kinase; COGs: COG3920 Signal transduction histidine kinase; InterPro IPR003660:IPR011495; KEGG: sta:STHERM_c11210 hypothetical protein; PFAM: Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor region; HAMP linker domain; SPTR: Signal transduction histidine kinase.
  
     0.769
AEJ61459.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; InterProIPR001789:IPR013767:IPR003661:IPR003594:IPR 000014; KEGG: sta:STHERM_c11530 hypothetical protein; PFAM: ATP-binding region, ATPase-like; Signal transduction response regulator, receiver region; PAS fold; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; SMART: Signal transdu [...]
 
 
 
 0.683
AEJ62092.1
PFAM: Histidine kinase; Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG3920 Signal transduction histidine kinase; InterProIPR001789:IPR013767:IPR011495:IPR003594:IPR 000014; KEGG: sta:STHERM_c17620 sensor histidine kinase; PFAM: ATP-binding region, ATPase-like; PAS fold; Signal transduction response regulator, receiver region; Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor region; SMART: Signal transduction response regulator, receiver region; PAS; ATP-binding [...]
 
  
0.661
AEJ60715.1
Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: EAL domain; Response regulator receiver domain; GGDEF domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG2200 FOG: EAL domain; InterProIPR000014:IPR000160:IPR001789:IPR001633:IPR 013767; KEGG: sta:STHERM_c04670 hypothetical protein; PFAM: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; Signal transduction response regulator, receiver region; PAS fold; SMART: Diguanylate phosphodiesterase, predicted; Diguanylate cyclas [...]
 
 
 
 0.653
rpsI
PFAM: Ribosomal protein S9/S16; COGs: COG0103 Ribosomal protein S9; InterPro IPR000754; KEGG: sta:STHERM_c21160 30S ribosomal protein S9; PFAM: Ribosomal protein S9; SPTR: 30S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family.
     
 0.612
recX
Regulatory protein recX; Modulates RecA activity; Belongs to the RecX family.
       0.603
rplM
Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
     
 0.601
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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