STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ62479.1Cobyrinic acid ac-diamide synthase; PFAM: CobQ/CobB/MinD/ParA nucleotide binding domain; COGs: COG1192 ATPase involved in chromosome partitioning; InterPro IPR002586; KEGG: sta:STHERM_c21780 cobyrinic acid a,c-diamide synthase; PFAM: Cobyrinic acid a,c-diamide synthase; SPTR: ParaA family ATPase. (255 aa)    
Predicted Functional Partners:
AEJ62546.1
parB-like partition protein; PFAM: Helix-turn-helix; ParB-like nuclease domain; TIGRFAM: ParB-like partition proteins; COGs: COG1475 transcriptional regulator protein; InterPro IPR004437:IPR003115; KEGG: sta:STHERM_c22510 chromosome 1-partitioning protein ParB; PFAM: ParB-like nuclease; SMART: ParB-like nuclease; SPTR: ParB-like partition protein; TIGRFAM: ParB-like partition protein.
 
 
 0.911
AEJ62478.1
KEGG: sta:STHERM_c21770 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.741
AEJ61706.1
PFAM: ParB-like nuclease domain; TIGRFAM: ParB-like partition proteins; InterPro IPR003115; KEGG: sta:STHERM_c07140 ParB-like nuclease domain-containing protein; PFAM: ParB-like nuclease; SMART: ParB-like nuclease; SPTR: ParB domain protein nuclease.
 
 
 0.740
pheS
PFAM: tRNA synthetases class II core domain (F); TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit; COGs: COG0016 Phenylalanyl-tRNA synthetase alpha subunit; HAMAP: Phenylalanyl-tRNA synthetase alpha chain; InterPro IPR004529:IPR002319; KEGG: sta:STHERM_c21750 phenylalanyl-tRNA synthetase, alpha subunit; PFAM: Phenylalanyl-tRNA synthetase alpha chain; SPTR: Phenylalanyl-tRNA synthetase alpha chain; TIGRFAM: Phenylalanyl-tRNA synthetase, class IIc, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
  
    0.562
pheT
Phenylalanyl-tRNA synthetase beta chain; PFAM: tRNA synthetases class II core domain (F); tRNA synthetase B5 domain; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; COGs: COG0072 Phenylalanyl-tRNA synthetase beta subunit; HAMAP: Phenylalanyl-tRNA synthetase beta chain; InterPro IPR004531:IPR005147; KEGG: sta:STHERM_c21760 phenylalanyl-tRNA synthetase subunit beta; PFAM: tRNA synthetase, B5; SPTR: Phenylalanyl-tRNA synthetase beta chain; TIGRFAM: Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archae/euk cytosolic.
       0.543
AEJ62474.1
PFAM: Rhomboid family; COGs: COG0705 membrane protein; InterPro IPR002610; KEGG: sta:STHERM_c21730 rhomboid family protein; PFAM: Peptidase S54, rhomboid; SPTR: Rhomboid family protein.
  
    0.430
AEJ62475.1
KEGG: sta:STHERM_c21740 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.418
ftsZ
Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
  
  
 0.410
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.402
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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