STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
AEJ62500.1Integral membrane sensor signal transduction histidine kinase; PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; COGs: COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation; InterPro IPR003660:IPR003661:IPR003594; KEGG: sta:STHERM_c21990 nitrogen regulation protein NtrY; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; HAMP linker domain; SMART: ATP-binding region, ATPase-like; Signal transduction hi [...] (584 aa)    
Predicted Functional Partners:
AEJ62501.1
Two component, sigma54 specific, transcriptional regulator, Fis family; PFAM: Response regulator receiver domain; Bacterial regulatory protein, Fis family; Sigma-54 interaction domain; COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterPro IPR001789:IPR002078:IPR002197:IPR003593; KEGG: sta:STHERM_c22000 transcriptional regulatory protein; PFAM: RNA polymerase sigma factor 54, interaction; Signal transduction response regulator, receiver region; Helix-turn-helix, Fis-type; SMART: Signal transduction response regulator, receiver r [...]
 
 0.989
AEJ62300.1
PFAM: Response regulator receiver domain; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789; KEGG: sta:STHERM_c19930 transcriptional regulatory protein; PFAM: Signal transduction response regulator, receiver region; SMART: Signal transduction response regulator, receiver region; SPTR: Response regulator receiver protein.
 
 
 
 0.835
AEJ62503.1
PFAM: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit; COGs: COG1466 DNA polymerase III delta subunit; InterPro IPR005790:IPR010372; KEGG: sta:STHERM_c22020 hypothetical protein; PFAM: DNA polymerase III, delta; SPTR: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit.
 
     0.824
AEJ61089.1
PFAM: Response regulator receiver domain; COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterPro IPR001789; KEGG: sta:STHERM_c14180 response regulator; PFAM: Signal transduction response regulator, receiver region; SMART: Signal transduction response regulator, receiver region; SPTR: Response regulator receiver protein.
 
 
 0.823
AEJ60392.1
PFAM: Response regulator receiver domain; COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterPro IPR001789; KEGG: sta:STHERM_c01170 hypothetical protein; PFAM: Signal transduction response regulator, receiver region; SMART: Signal transduction response regulator, receiver region; SPTR: Response regulator receiver protein.
  
 
 
 0.814
AEJ60839.1
Two component transcriptional regulator, winged helix family; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789:IPR001867; KEGG: sta:STHERM_c05370 transcriptional regulatory protein; PFAM: Signal transduction response regulator, receiver region; Signal transduction response regulator, C-terminal; SMART: Signal transduction response regulator, receiver region; SPTR: Two component transcriptional regulator, winged he [...]
  
 
 
 0.812
AEJ60863.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR001789:IPR003594; KEGG: sta:STHERM_c05630 two-component regulatory system response regulator; PFAM: Signal transduction response regulator, receiver region; ATP-binding region, ATPase-like; SMART: Signal transduction response regulator, receiver region; SPTR: Response regulator receiver sensor signal transduction histidine kinase.
 
 
 0.805
lexA
SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
       0.801
hprK
HPr kinase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
 
     0.787
AEJ62498.1
Phosphotransferase system, phosphocarrier protein HPr; PFAM: PTS HPr component phosphorylation site; TIGRFAM: Phosphotransferase System HPr (HPr) Family; COGs: COG1925 Phosphotransferase system HPr-related protein; InterPro IPR005698; KEGG: sta:STHERM_c21970 phosphocarrier protein HPr; PFAM: Phosphotransferase system, phosphocarrier HPr protein; SPTR: Phosphocarrier protein HPr; TIGRFAM: Phosphotransferase system, phosphocarrier HPr protein.
       0.786
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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