STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
AEJ62501.1Two component, sigma54 specific, transcriptional regulator, Fis family; PFAM: Response regulator receiver domain; Bacterial regulatory protein, Fis family; Sigma-54 interaction domain; COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterPro IPR001789:IPR002078:IPR002197:IPR003593; KEGG: sta:STHERM_c22000 transcriptional regulatory protein; PFAM: RNA polymerase sigma factor 54, interaction; Signal transduction response regulator, receiver region; Helix-turn-helix, Fis-type; SMART: Signal transduction response regulator, receiver r [...] (456 aa)    
Predicted Functional Partners:
AEJ62500.1
Integral membrane sensor signal transduction histidine kinase; PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; COGs: COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation; InterPro IPR003660:IPR003661:IPR003594; KEGG: sta:STHERM_c21990 nitrogen regulation protein NtrY; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; HAMP linker domain; SMART: ATP-binding region, ATPase-like; Signal transduction hi [...]
 
 0.989
AEJ62495.1
RNA polymerase, sigma 54 subunit, RpoN; PFAM: Sigma-54 factor, Activator interacting domain (AID); Sigma-54 factor, core binding domain; Sigma-54, DNA binding domain; TIGRFAM: RNA polymerase sigma-54 factor; COGs: COG1508 DNA-directed RNA polymerase specialized sigma subunit sigma54 homolog; InterPro IPR000394:IPR007046:IPR007634; KEGG: sta:STHERM_c21940 RNA polymerase sigma-54 factor; PFAM: RNA polymerase sigma factor 54, DNA-binding; RNA polymerase sigma factor 54; RNA polymerase sigma factor 54, core-binding; SPTR: RNA polymerase, sigma 54 subunit, RpoN; TIGRFAM: RNA polymerase sigm [...]
 
   
 0.935
lexA
SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
     
 0.806
AEJ62503.1
PFAM: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit; COGs: COG1466 DNA polymerase III delta subunit; InterPro IPR005790:IPR010372; KEGG: sta:STHERM_c22020 hypothetical protein; PFAM: DNA polymerase III, delta; SPTR: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit.
       0.800
AEJ61223.1
Flagellar motor switch protein FliN; FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. Belongs to the FliN/MopA/SpaO family.
  
  
 0.785
AEJ62498.1
Phosphotransferase system, phosphocarrier protein HPr; PFAM: PTS HPr component phosphorylation site; TIGRFAM: Phosphotransferase System HPr (HPr) Family; COGs: COG1925 Phosphotransferase system HPr-related protein; InterPro IPR005698; KEGG: sta:STHERM_c21970 phosphocarrier protein HPr; PFAM: Phosphotransferase system, phosphocarrier HPr protein; SPTR: Phosphocarrier protein HPr; TIGRFAM: Phosphotransferase system, phosphocarrier HPr protein.
     
 0.780
AEJ62499.1
KEGG: sta:STHERM_c21980 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.773
hprK
HPr kinase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
       0.754
AEJ62496.1
PFAM: Sigma 54 modulation protein / S30EA ribosomal protein; TIGRFAM: ribosomal subunit interface protein; InterPro IPR003489; KEGG: sta:STHERM_c21950 hypothetical protein; PFAM: Ribosomal protein S30Ae/sigma 54 modulation protein; SPTR: Ribosomal subunit interface protein; TIGRFAM: Ribosomal protein S30Ae/sigma 54 modulation protein.
     
 0.745
AEJ60845.1
Signal transduction histidine kinase, nitrogen specific, NtrB; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG3852 Signal transduction histidine kinase nitrogen specific; InterPro IPR000014:IPR003661:IPR003594:IPR013656; KEGG: sta:STHERM_c05430 sensory transduction histidine kinase; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; PAS fold-4; SMART: ATP-binding region, ATPase-like; Signal transduction histidine [...]
 
 
 0.728
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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