STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ62523.1PFAM: Phosphorylase superfamily; TIGRFAM: purine-nucleoside phosphorylase, family 1 (deoD); COGs: COG0813 Purine-nucleoside phosphorylase; HAMAP: Purine nucleoside phosphorylase deoD-type; InterPro IPR004402:IPR000845; KEGG: sta:STHERM_c22230 purine nucleoside phosphorylase DeoD-type; PFAM: Nucleoside phosphorylase; SPTR: Purine-nucleoside phosphorylase; TIGRFAM: Purine nucleoside phosphorylase. (239 aa)    
Predicted Functional Partners:
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
    
 0.920
AEJ61050.1
PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region; COGs: COG0295 Cytidine deaminase; InterPro IPR002125; KEGG: sta:STHERM_c14570 hypothetical protein; PFAM: CMP/dCMP deaminase, zinc-binding; SPTR: CMP/dCMP deaminase zinc-binding.
  
 
 0.919
AEJ61184.1
Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.
  
 
 0.919
AEJ61716.1
Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.
     
 0.912
AEJ62549.1
PFAM: Adenosine/AMP deaminase; TIGRFAM: adenosine deaminase; COGs: COG1816 Adenosine deaminase; HAMAP: Adenosine deaminase; InterPro IPR006330:IPR001365; KEGG: sta:STHERM_c22540 adenosine deaminase; PFAM: Adenosine/AMP deaminase; SPTR: Adenosine deaminase; TIGRFAM: Adenosine deaminase.
    
 0.912
surE
Multifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.904
AEJ61717.1
PFAM: Isochorismatase family; COGs: COG1335 Amidase related to nicotinamidase; InterPro IPR000868; KEGG: sta:STHERM_c07030 hypothetical protein; PFAM: Isochorismatase-like; SPTR: Nicotinamidase.
    
  0.902
AEJ61624.1
PFAM: FAD binding domain in molybdopterin dehydrogenase; COGs: COG1319 Aerobic-type carbon monoxide dehydrogenase middle subunit CoxM/CutM homologs; InterPro IPR002346; KEGG: sta:STHERM_c08100 xanthine dehydrogenase subunit, FAD-binding domain-containing protein; PFAM: Molybdopterin dehydrogenase, FAD-binding; SPTR: Molybdopterin dehydrogenase FAD-binding.
     
  0.900
AEJ61809.1
Metal-dependent phosphohydrolase HD sub domain-containing protein; PFAM: HD domain; TIGRFAM: deoxyguanosinetriphosphate triphosphohydrolase, putative; COGs: COG0232 dGTP triphosphohydrolase; InterPro IPR003607:IPR006674; KEGG: sta:STHERM_c14100 deoxyguanosinetriphosphate triphosphohydrolase-like protein; PFAM: Metal-dependent phosphohydrolase, HD region, subdomain; SMART: Metal-dependent phosphohydrolase, HD region; SPTR: Metal-dependent phosphohydrolase HD sub domain; Belongs to the dGTPase family. Type 2 subfamily.
     
  0.900
AEJ62524.1
PFAM: Biotin/lipoate A/B protein ligase family; TIGRFAM: lipoyltransferase and lipoate-protein ligase; COGs: COG0095 Lipoate-protein ligase A; InterPro IPR004143; KEGG: sta:STHERM_c22240 lipoate-protein ligase A; PFAM: Biotin/lipoate A/B protein ligase; SPTR: Lipoate--protein ligase.
       0.779
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.