STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEJ62524.1PFAM: Biotin/lipoate A/B protein ligase family; TIGRFAM: lipoyltransferase and lipoate-protein ligase; COGs: COG0095 Lipoate-protein ligase A; InterPro IPR004143; KEGG: sta:STHERM_c22240 lipoate-protein ligase A; PFAM: Biotin/lipoate A/B protein ligase; SPTR: Lipoate--protein ligase. (292 aa)    
Predicted Functional Partners:
AEJ62280.1
Transketolase domain-containing protein; PFAM: Dehydrogenase E1 component; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; Transketolase, C-terminal domain; Biotin-requiring enzyme; Transketolase, pyrimidine binding domain; TIGRFAM: 3-oxoacyl-(acyl-carrier-protein) synthase III; COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; InterProIPR001017:IPR005475:IPR005476:IPR000089:IPR 013751:IPR013747; KEGG: sta:STHERM_c19760 hypothetical protein; PFAM: Tr [...]
 
 0.968
lipA
Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
  
 
 0.931
lipB
Octanoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
   
 0.923
AEJ60373.1
PFAM: Acyl-ACP thioesterase; COGs: COG3884 Acyl-ACP thioesterase; InterPro IPR002864; KEGG: sta:STHERM_c00990 acyl-ACP thioesterase; PFAM: Acyl-ACP thioesterase; SPTR: Acyl-ACP thioesterase.
     
  0.900
AEJ61610.1
Transketolase central region; PFAM: Dehydrogenase E1 component; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain; COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; InterPro IPR001017:IPR005475:IPR005476; KEGG: sta:STHERM_c08250 dehydrogenase, fusion; PFAM: Transketolase-like, pyrimidine-binding domain; Dehydrogenase, E1 component; Transketolase, C-terminal; SPTR: Transketolase central region.
 
 
 0.888
AEJ61013.1
Dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase; COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterPro IPR006258:IPR013027:IPR004099; KEGG: sta:STHERM_c14890 dihydrolipoyl dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation; SPTR: Dihydrolipoyl dehydrogenase; TIGRFAM: Dihydrolipoamide dehydrogenase.
 
 
 0.884
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 
 0.838
gcvH-2
Glycine cleavage H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 
 0.835
AEJ62523.1
PFAM: Phosphorylase superfamily; TIGRFAM: purine-nucleoside phosphorylase, family 1 (deoD); COGs: COG0813 Purine-nucleoside phosphorylase; HAMAP: Purine nucleoside phosphorylase deoD-type; InterPro IPR004402:IPR000845; KEGG: sta:STHERM_c22230 purine nucleoside phosphorylase DeoD-type; PFAM: Nucleoside phosphorylase; SPTR: Purine-nucleoside phosphorylase; TIGRFAM: Purine nucleoside phosphorylase.
       0.779
AEJ62525.1
KEGG: sta:STHERM_c22250 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.773
Your Current Organism:
Spirochaeta thermophila
NCBI taxonomy Id: 869211
Other names: S. thermophila DSM 6578, Spirochaeta thermophila DSM 6578, Spirochaeta thermophila str. DSM 6578, Spirochaeta thermophila strain DSM 6578
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