STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fhsPFAM: Formate--tetrahydrofolate ligase; COGs: COG2759 Formyltetrahydrofolate synthetase; HAMAP: Formate-tetrahydrofolate ligase, FTHFS; InterPro IPR000559; KEGG: Formate--tetrahydrofolate ligase; PFAM: Formate-tetrahydrofolate ligase, FTHFS; SPTR: Formate--tetrahydrofolate ligase. (573 aa)    
Predicted Functional Partners:
folD
5,10-methylenetetrahydrofolate dehydrogenase (NADP+), methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
 
 
 0.994
purH
PFAM: AICARFT/IMPCHase bienzyme; MGS-like domain; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); HAMAP: Bifunctional purine biosynthesis protein purH; InterPro IPR002695:IPR013982:IPR011607; KEGG: cja:CJA_2747 bifunctional purine biosynthesis protein PurH; PFAM: AICARFT/IMPCHase bienzyme, formylation region; MGS-like; SMART: AICARFT/IMPCHase bienzyme, formylation region; SPTR: Bifunctional purine biosynthesis protein purH; TIGRFAM: AICARFT/IMPCHas [...]
  
 0.975
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.966
purN
Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
  
 0.966
AFM12772.1
Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.958
AFM12279.1
PFAM: Aminomethyltransferase folate-binding domain; Glycine cleavage T-protein C-terminal barrel domain; TIGRFAM: glycine cleavage system T protein; COGs: COG0404 Glycine cleavage system T protein (aminomethyltransferase); InterPro IPR006222:IPR013977:IPR006223; KEGG: lic:LIC10311 glycine cleavage system aminomethyltransferase T; PFAM: Glycine cleavage T-protein, N-terminal; Glycine cleavage T-protein, C-terminal barrel; SPTR: Aminomethyltransferase; TIGRFAM: Glycine cleavage system T protein.
  
 0.949
purT
Formate-dependent phosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family.
     
  0.900
purC
PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; COGs: COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; HAMAP: Phosphoribosylaminoimidazole-succinocarboxamide synthase; InterPro IPR001636; KEGG: lbl:LBL_2381 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; SPTR: Phosphoribosylaminoimidazole-succinocarboxamide synthase.
  
 
 0.856
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
  
  
 0.810
purL
Phosphoribosylformylglycinamidine synthase 2; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...]
  
 
 0.773
Your Current Organism:
Turneriella parva
NCBI taxonomy Id: 869212
Other names: T. parva DSM 21527, Turneriella parva DSM 21527, Turneriella parva H, Turneriella parva NCTC 11395, Turneriella parva str. DSM 21527, Turneriella parva strain DSM 21527
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.