STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
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[Homology]
Score
AFM14699.1Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. (297 aa)    
Predicted Functional Partners:
sucD
succinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
    
 0.918
sucC
succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
   
 
 0.913
AFM11972.1
PFAM: Malate synthase; TIGRFAM: malate synthase A; COGs: COG2225 Malate synthase; InterPro IPR006252:IPR011076; KEGG: hse:Hsero_3029 malate synthase; PFAM: Malate synthase-like, core; SPTR: Malate synthase; TIGRFAM: Malate synthase A; Belongs to the malate synthase family.
   
 
 0.901
acsA
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 
 0.890
AFM13677.1
AMP-dependent synthetase and ligase; PFAM: AMP-binding enzyme; COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873; KEGG: kko:Kkor_1563 AMP-dependent synthetase and ligase; PFAM: AMP-dependent synthetase/ligase; SPTR: AMP-dependent synthetase and ligase.
  
 
 0.890
AFM12426.1
PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; Biotin carboxylase C-terminal domain; Carbamoyl-phosphate synthase L chain, N-terminal domain; COGs: COG4770 Acetyl/propionyl-CoA carboxylase alpha subunit; InterPro IPR005481:IPR005479:IPR005482; KEGG: purK; putative Methylcrotonoyl-Coenzyme A carboxylase 1 (alpha); PFAM: Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthase, large subunit, N-terminal; Biotin carboxylase, C-terminal; SPTR: Putative Methylcrotonoyl-Coenzyme A carboxylase 1 (Alpha).
  
 0.833
AFM12596.1
PFAM: Thiolase, C-terminal domain; Thiolase, N-terminal domain; COGs: COG0183 Acetyl-CoA acetyltransferase; KEGG: gur:Gura_4354 thiolase; SPTR: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.830
AFM13406.1
acetyl-CoA acetyltransferase; PFAM: Thiolase, C-terminal domain; Thiolase, N-terminal domain; TIGRFAM: acetyl-CoA acetyltransferases; COGs: COG0183 Acetyl-CoA acetyltransferase; InterPro IPR002155; KEGG: lbl:LBL_2507 acetyl-CoA acetyltransferase; SPTR: Acetyl-CoA acetyltransferase; TIGRFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.830
AFM14264.1
propanoyl-CoA C-acyltransferase; COGs: COG0183 Acetyl-CoA acetyltransferase; KEGG: dal:Dalk_4047 propanoyl-CoA C-acyltransferase; SPTR: Propanoyl-CoA C-acyltransferase.
  
 
 0.830
AFM14265.1
propanoyl-CoA C-acyltransferase; COGs: COG0183 Acetyl-CoA acetyltransferase; KEGG: dal:Dalk_4048 propanoyl-CoA C-acyltransferase; SPTR: Propanoyl-CoA C-acyltransferase.
  
 
 0.830
Your Current Organism:
Turneriella parva
NCBI taxonomy Id: 869212
Other names: T. parva DSM 21527, Turneriella parva DSM 21527, Turneriella parva H, Turneriella parva NCTC 11395, Turneriella parva str. DSM 21527, Turneriella parva strain DSM 21527
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