STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (927 aa)    
Predicted Functional Partners:
EIJ35015.1
PFAM: DNA polymerase III beta subunit, C-terminal domain; DNA polymerase III beta subunit, N-terminal domain; DNA polymerase III beta subunit, central domain; TIGRFAM: DNA polymerase III, beta subunit; COGs: COG0592 DNA polymerase sliding clamp subunit (PCNA homolog); InterPro IPR001001; KEGG: tgr:Tgr7_0002 DNA polymerase III, beta subunit; PFAM: DNA polymerase III, beta chain; SMART: DNA polymerase III, beta chain; SPTR: DNA polymerase III, beta subunit; TIGRFAM: DNA polymerase III, beta chain.
 
 0.999
recA
Protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
 
 0.999
EIJ34809.1
Metallophosphoesterase; PFAM: Calcineurin-like phosphoesterase; COGs: COG0420 DNA repair exonuclease; InterPro IPR004843; KEGG: dat:HRM2_43350 DNA repair exonuclease family protein; PFAM: Metallophosphoesterase; SPTR: Ser/Thr protein phosphatase family protein.
   
 0.995
EIJ34014.1
DNA mismatch repair protein MutS; PFAM: MutS family domain IV; MutS domain II; MutS domain V; MutS domain I; MutS domain III; TIGRFAM: DNA mismatch repair protein MutS; COGs: COG0249 Mismatch repair ATPase (MutS family); HAMAP: DNA mismatch repair protein MutS, type 1; InterProIPR005748:IPR007695:IPR007860:IPR007696:IPR 007861:IPR000432; KEGG: tgr:Tgr7_1282 DNA mismatch repair protein MutS; PFAM: DNA mismatch repair protein MutS, C-terminal; DNA mismatch repair protein MutS, core; DNA mismatch repair protein MutS-like, N-terminal; DNA mismatch repair protein MutS, connector; DNA mismat [...]
  
 0.992
EIJ35577.1
ATP-dependent DNA helicase RecQ; PFAM: Helicase conserved C-terminal domain; RQC domain; HRDC domain; DEAD/DEAH box helicase; TIGRFAM: ATP-dependent DNA helicase RecQ; ATP-dependent DNA helicase, RecQ family; COGs: COG0514 Superfamily II DNA helicase; InterProIPR014001:IPR001650:IPR002121:IPR006293:IPR 018329:IPR011545:IPR018982; KEGG: tgr:Tgr7_1931 ATP-dependent DNA helicase RecQ; PFAM: RQC domain; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; DNA/RNA helicase, C-terminal; Helicase/RNase D C-terminal, HRDC domain; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal [...]
  
 0.992
EIJ35544.1
DNA mismatch repair protein MutL; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; MutL C terminal dimerisation domain; DNA mismatch repair protein, C-terminal domain; TIGRFAM: DNA mismatch repair protein MutL; COGs: COG0323 DNA mismatch repair enzyme (predicted ATPase); HAMAP: DNA mismatch repair protein mutL; InterPro IPR014763:IPR003594:IPR013507:IPR014790; KEGG: tgr:Tgr7_0895 DNA mismatch repair protein MutL; PFAM: MutL, C-terminal, dimerisation; DNA mismatch repair protein, C-terminal; ATP-binding region, ATPase-like; SPTR: DNA mismatch repair protein mutL; TIGRFAM: [...]
   
 0.988
EIJ36181.1
PFAM: Type III restriction enzyme, res subunit; InterPro IPR006935; KEGG: swd:Swoo_0304 type III restriction protein res subunit; PFAM: Restriction endonuclease, type I, R subunit/Type III, Res subunit; SPTR: Type III restriction protein res subunit.
  
 0.987
EIJ36586.1
Helicase c2; PFAM: DEAD_2; COGs: COG1199 Rad3-related DNA helicase; InterPro IPR006555; KEGG: nhl:Nhal_2019 helicase C2; SMART: Helicase, ATP-dependent, c2 type; SPTR: Helicase c2.
   
 0.982
EIJ34399.1
SMC domain protein; PFAM: RecF/RecN/SMC N terminal domain; COGs: COG0419 ATPase involved in DNA repair; InterPro IPR003395; KEGG: mgm:Mmc1_3265 DNA repair ATPase-like protein; PFAM: RecF/RecN/SMC protein, N-terminal; SPTR: ATPase involved in DNA repair-like protein.
  
 0.978
EIJ34012.1
SNF2-related protein; PFAM: Helicase conserved C-terminal domain; SNF2 family N-terminal domain; COGs: COG0553 Superfamily II DNA/RNA helicase SNF2 family; InterPro IPR007527:IPR000330:IPR001650:IPR014001; KEGG: hch:HCH_06999 SNF2 family DNA/RNA helicase; PFAM: SNF2-related; Zinc finger, SWIM-type; DNA/RNA helicase, C-terminal; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; SPTR: SNF2-related protein.
  
 0.968
Your Current Organism:
Thiothrix nivea
NCBI taxonomy Id: 870187
Other names: T. nivea DSM 5205, Thiothrix nivea DSM 5205, Thiothrix nivea JP2, Thiothrix nivea str. DSM 5205, Thiothrix nivea strain DSM 5205
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.