STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EIJ34584.1PFAM: Preprotein translocase subunit SecB; TIGRFAM: protein-export chaperone SecB; COGs: COG1952 Preprotein translocase subunit SecB; HAMAP: Bacterial protein export chaperone SecB; InterPro IPR003708; KEGG: shm:Shewmr7_0045 preprotein translocase subunit SecB; PFAM: Bacterial protein export chaperone SecB; SPTR: Protein-export protein secB; TIGRFAM: Bacterial protein export chaperone SecB. (151 aa)    
Predicted Functional Partners:
secA
Protein translocase subunit secA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family.
   
 0.998
EIJ34585.1
PFAM: Glutaredoxin; TIGRFAM: Glutaredoxin, GrxC family; COGs: COG0695 Glutaredoxin and related protein; InterPro IPR002109:IPR011900; KEGG: rcp:RCAP_rcc00198 glutaredoxin; PFAM: Glutaredoxin; SPTR: Glutaredoxin 3; TIGRFAM: Glutaredoxin, GrxC.
  
  
 0.971
EIJ34166.1
KEGG: cyn:Cyan7425_4772 hypothetical protein; SPTR: Putative uncharacterized protein.
   
 0.963
EIJ35814.1
PFAM: SecE/Sec61-gamma subunits of protein translocation complex; Uncharacterised protein family (UPF0104); TIGRFAM: preprotein translocase, SecE subunit, bacterial; InterPro IPR001901:IPR005807; KEGG: tgr:Tgr7_2337 preprotein translocase subunit SecE; PFAM: Protein secE/sec61-gamma protein; SPTR: Preprotein translocase subunit SecE; TIGRFAM: SecE subunit of protein translocation complex.
  
 
 0.942
EIJ36349.1
PFAM: Preprotein translocase subunit; TIGRFAM: preprotein translocase, YajC subunit; COGs: COG1862 Preprotein translocase subunit YajC; InterPro IPR003849; KEGG: tgr:Tgr7_2067 preprotein translocase, YajC subunit; PFAM: YajC; SPTR: Preprotein translocase, YajC subunit; TIGRFAM: YajC.
   
 
 0.921
EIJ35020.1
Protein translocase subunit yidC; PFAM: 60Kd inner membrane protein; TIGRFAM: membrane protein insertase, YidC/Oxa1 family, C-terminal domain; membrane protein insertase, YidC/Oxa1 family, N-terminal domain; COGs: COG0706 Preprotein translocase subunit YidC; HAMAP: Membrane protein oxaA; InterPro IPR001708:IPR019998:IPR020001; KEGG: tgr:Tgr7_3318 protein translocase subunit YidC; PFAM: Membrane insertion protein, OxaA/YidC; SPTR: Inner membrane protein oxaA; TIGRFAM: Membrane insertion protein, OxoA/YidC, N-terminal; Membrane insertion protein, OxaA/YidC, core.
  
  
 0.919
EIJ34054.1
PFAM: Preprotein translocase SecG subunit; TIGRFAM: protein translocase, SecG subunit; COGs: COG1314 Preprotein translocase subunit SecG; InterPro IPR004692; KEGG: tkm:TK90_0707 preprotein translocase, SecG subunit; PFAM: Preprotein translocase SecG subunit; SPTR: Preprotein translocase, SecG subunit; TIGRFAM: Preprotein translocase SecG subunit.
   
 
 0.897
ftsY
Signal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
     
 0.895
secY
Preprotein translocase, SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
     
 0.895
ffh
Signal recognition particle subunit FFH/SRP54 (srp54); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the i [...]
     
 0.895
Your Current Organism:
Thiothrix nivea
NCBI taxonomy Id: 870187
Other names: T. nivea DSM 5205, Thiothrix nivea DSM 5205, Thiothrix nivea JP2, Thiothrix nivea str. DSM 5205, Thiothrix nivea strain DSM 5205
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