STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
EIJ35529.1Nucleoside-triphosphatase rdgB; PFAM: Ham1 family; TIGRFAM: non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; COGs: COG0127 Xanthosine triphosphate pyrophosphatase; HAMAP: Nucleoside-triphosphatase rdgB; InterPro IPR002637; KEGG: ecz:ECS88_3236 deoxyribonucleotide triphosphate pyrophosphatase; PFAM: Ham1-like protein; SPTR: Non-canonical purine NTP pyrophosphatase; TIGRFAM: Ham1-like protein. (196 aa)    
Predicted Functional Partners:
rph
RNAse PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
 
 
  0.994
dut
Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
   
 0.940
EIJ32768.1
PFAM: GMP synthase C terminal domain; Glutamine amidotransferase class-I; NAD synthase; TIGRFAM: GMP synthase (glutamine-hydrolyzing), C-terminal domain or B subunit; GMP synthase (glutamine-hydrolyzing), N-terminal domain or A subunit; COGs: COG0519 GMP synthase PP-ATPase domain/subunit; HAMAP: GMP synthase [glutamine-hydrolyzing]; InterPro IPR004739:IPR001674:IPR000991:IPR018318; KEGG: tgr:Tgr7_1036 GMP synthase; PFAM: GMP synthase, C-terminal; Glutamine amidotransferase class-I, C-terminal; tRNA methyl transferase-like; SPTR: GMP synthase [glutamine-hydrolyzing]; TIGRFAM: GMP syntha [...]
 
 
 0.938
EIJ35777.1
PFAM: Asp/Glu/Hydantoin racemase; TIGRFAM: glutamate racemase; COGs: COG0796 Glutamate racemase; HAMAP: Glutamate racemase; InterPro IPR004391:IPR015942; KEGG: pba:PSEBR_a4755 glutamate racemase; PFAM: Asp/Glu/hydantoin racemase; SPTR: Glutamate racemase; TIGRFAM: Glutamate racemase.
 
    0.909
EIJ33406.1
PFAM: Adenylosuccinate synthetase; TIGRFAM: adenylosuccinate synthase; COGs: COG0104 Adenylosuccinate synthase; HAMAP: Adenylosuccinate synthetase; InterPro IPR001114; KEGG: tkm:TK90_1939 adenylosuccinate synthetase; PFAM: Adenylosuccinate synthetase; SMART: Adenylosuccinate synthetase; SPTR: Adenylosuccinate synthetase; TIGRFAM: Adenylosuccinate synthetase.
 
 0.894
EIJ32767.1
PFAM: CBS domain; IMP dehydrogenase / GMP reductase domain; TIGRFAM: inosine-5'-monophosphate dehydrogenase; COGs: COG0516 IMP dehydrogenase/GMP reductase; InterPro IPR005990:IPR001093:IPR000644; KEGG: tgr:Tgr7_1035 inosine-5'-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; Cystathionine beta-synthase, core; SMART: Cystathionine beta-synthase, core; SPTR: Inosine-5'-monophosphate dehydrogenase; TIGRFAM: IMP dehydrogenase.
  
 0.884
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
  
  0.851
EIJ33981.1
Bifunctional purine biosynthesis protein purH; PFAM: AICARFT/IMPCHase bienzyme; MGS-like domain; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); HAMAP: Bifunctional purine biosynthesis protein purH; InterPro IPR002695:IPR011607:IPR013982; KEGG: cja:CJA_2747 bifunctional purine biosynthesis protein PurH; PFAM: AICARFT/IMPCHase bienzyme, formylation region; MGS-like; SMART: AICARFT/IMPCHase bienzyme, formylation region; SPTR: Bifunctional purine bios [...]
   
 
 0.835
EIJ33304.1
Phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: hypoxanthine phosphoribosyltransferase; COGs: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; InterPro IPR000836; KEGG: tgr:Tgr7_1752 hypoxanthine-guanine phosphoribosyltransferase; PFAM: Phosphoribosyltransferase; SPTR: Hypoxanthine-guanine phosphoribosyltransferase.
   
 
 0.810
EIJ34148.1
PFAM: Survival protein SurE; TIGRFAM: 5'/3'-nucleotidase SurE; COGs: COG0496 acid phosphatase; HAMAP: Multifunctional protein surE; InterPro IPR002828; KEGG: swp:swp_1361 stationary phase survival protein SurE; PFAM: Survival protein SurE-like phosphatase/nucleotidase; SPTR: 5'-nucleotidase surE; TIGRFAM: Survival protein SurE-like phosphatase/nucleotidase; manually curated.
     
  0.806
Your Current Organism:
Thiothrix nivea
NCBI taxonomy Id: 870187
Other names: T. nivea DSM 5205, Thiothrix nivea DSM 5205, Thiothrix nivea JP2, Thiothrix nivea str. DSM 5205, Thiothrix nivea strain DSM 5205
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