STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EIJ35985.1TIGRFAM: HAD-superfamily subfamily IB hydrolase, TIGR01490; Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; COGs: COG0560 Phosphoserine phosphatase; InterPro IPR006383:IPR006385; KEGG: mpc:Mar181_0621 HAD-superfamily hydrolase; SPTR: HAD-superfamily subfamily IB hydrolase, TIGR01490; TIGRFAM: HAD-superfamily hydrolase, subfamily IB, PSPase-like, bacterial; HAD-superfamily hydrolase, subfamily IB, PSPase-like. (221 aa)    
Predicted Functional Partners:
EIJ36529.1
Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    
 0.924
EIJ32839.1
PFAM: Aminotransferase class-V; TIGRFAM: phosphoserine aminotransferase; COGs: COG1932 Phosphoserine aminotransferase; HAMAP: Phosphoserine aminotransferase; InterPro IPR003248:IPR000192; KEGG: tgr:Tgr7_1536 phosphoserine aminotransferase; PFAM: Aminotransferase, class V/Cysteine desulfurase; SPTR: Phosphoserine aminotransferase; TIGRFAM: Phosphoserine aminotransferase.
  
 
 0.876
hisF
Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
  
 0.869
EIJ33405.1
TIGRFAM: ATP phosphoribosyltransferase, regulatory subunit; COGs: COG3705 ATP phosphoribosyltransferase involved in histidine biosynthesis; HAMAP: ATP phosphoribosyltransferase regulatory subunit; InterPro IPR004517:IPR002314; KEGG: tgr:Tgr7_0902 histidyl-tRNA synthetase 2; PFAM: Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved region; SPTR: ATP phosphoribosyltransferase regulatory subunit; TIGRFAM: Histidyl-tRNA synthetase, class IIa, putative.
 
    0.865
EIJ33541.1
PFAM: Serine hydroxymethyltransferase; COGs: COG0112 Glycine/serine hydroxymethyltransferase; InterPro IPR001085; KEGG: tgr:Tgr7_1557 serine hydroxymethyltransferase; PFAM: Serine hydroxymethyltransferase; SPTR: Serine hydroxymethyltransferase.
  
 0.840
EIJ35271.1
PFAM: Imidazoleglycerol-phosphate dehydratase; COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; HAMAP: Imidazoleglycerol-phosphate dehydratase; InterPro IPR000807; KEGG: pag:PLES_55341 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase; SPTR: Imidazoleglycerol-phosphate dehydratase.
  
  
 0.829
EIJ35272.1
PFAM: Glutamine amidotransferase class-I; TIGRFAM: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; COGs: COG0118 Glutamine amidotransferase; HAMAP: Imidazole glycerol phosphate synthase, subunit H; InterPro IPR000991:IPR010139; KEGG: ppf:Pput_0310 imidazole glycerol phosphate synthase subunit HisH; PFAM: Glutamine amidotransferase class-I, C-terminal; SPTR: Glutamine amidotransferase HisH; TIGRFAM: Imidazole glycerol phosphate synthase, subunit H.
  
  
 0.811
hisA
1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; HAMAP:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; InterPro IPR006062:IPR006063; KEGG: maq:Maqu_3171 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: Histi [...]
  
  
 0.799
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
  
 0.744
EIJ33889.1
TIGRFAM: serine O-acetyltransferase; COGs: COG1045 Serine acetyltransferase; InterPro IPR005881:IPR001451; KEGG: alv:Alvin_0863 serine O-acetyltransferase; SPTR: Serine acetyltransferase; TIGRFAM: Serine O-acetyltransferase.
    
 0.742
Your Current Organism:
Thiothrix nivea
NCBI taxonomy Id: 870187
Other names: T. nivea DSM 5205, Thiothrix nivea DSM 5205, Thiothrix nivea JP2, Thiothrix nivea str. DSM 5205, Thiothrix nivea strain DSM 5205
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