Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
EIJ36679.1PFAM: RecF/RecN/SMC N terminal domain; TIGRFAM: DNA repair protein RecN; COGs: COG0497 ATPase involved in DNA repair; InterPro IPR004604:IPR003395; KEGG: tgr:Tgr7_0968 DNA repair protein RecN; PFAM: RecF/RecN/SMC protein, N-terminal; SPTR: DNA repair protein RecN; TIGRFAM: DNA recombination/repair protein RecN. (553 aa)    
Predicted Functional Partners:
recA
Protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
  
 0.927
EIJ35022.1
SOS-response transcriptional repressor, LexA; PFAM: LexA DNA binding domain; Peptidase S24-like; TIGRFAM: SOS regulatory protein LexA; COGs: COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidase); InterPro IPR006199:IPR019759:IPR006200; KEGG: tgr:Tgr7_3074 repressor LexA; PFAM: Peptidase S24/S26A/S26B, conserved region; LexA DNA-binding region; SPTR: LexA repressor; TIGRFAM: Peptidase S24, LexA repressor.
  
  
 0.916
EIJ36678.1
PFAM: ATP-NAD kinase; COGs: COG0061 sugar kinase; HAMAP: inorganic polyphosphate/ATP-NAD kinase; InterPro IPR002504; KEGG: nhl:Nhal_0879 ATP-NAD/AcoX kinase; PFAM: ATP-NAD/AcoX kinase; SPTR: Probable inorganic polyphosphate/ATP-NAD kinase.
     
 0.849
EIJ36677.1
Heat-inducible transcription repressor HrcA; PFAM: Domain of unknown function; HrcA protein C terminal domain; TIGRFAM: heat shock gene repressor HrcA; COGs: COG1420 Transcriptional regulator of heat shock gene; HAMAP: Negative regulator of class I heat shock protein; InterPro IPR002571; KEGG: tgr:Tgr7_0970 heat-inducible transcription repressor HrcA; PFAM: Negative regulator of class I heat shock protein; SPTR: Heat-inducible transcription repressor hrcA; TIGRFAM: Negative regulator of class I heat shock protein.
 
   
 0.753
EIJ32764.1
PFAM: Exonuclease VII, large subunit; OB-fold nucleic acid binding domain; TIGRFAM: exodeoxyribonuclease VII, large subunit; COGs: COG1570 Exonuclease VII large subunit; HAMAP: Exodeoxyribonuclease 7 large subunit; InterPro IPR003753:IPR004365:IPR020579; KEGG: aeh:Mlg_0693 exodeoxyribonuclease VII large subunit; PFAM: Exonuclease VII, large subunit, C-terminal; Nucleic acid binding, OB-fold, tRNA/helicase-type; SPTR: Exodeoxyribonuclease 7 large subunit; TIGRFAM: Exonuclease VII, large subunit.
 
   
 0.711
EIJ34637.1
PFAM: RuvA, C-terminal domain; RuvA N terminal domain; TIGRFAM: Holliday junction DNA helicase, RuvA subunit; COGs: COG0632 Holliday junction resolvasome DNA-binding subunit; HAMAP: Holliday junction ATP-dependent DNA helicase ruvA; InterPro IPR013849:IPR011114:IPR003583:IPR000085; KEGG: tgr:Tgr7_2235 Holliday junction DNA helicase RuvA; PFAM: DNA helicase, Holliday junction RuvA type, domain I, bacterial; DNA helicase, Holliday junction RuvA type, domain III, C-terminal; SPTR: Holliday junction ATP-dependent DNA helicase ruvA; TIGRFAM: Bacterial DNA recombination protein RuvA.
  
  
 0.708
EIJ32978.1
Excinuclease ABC subunit C; PFAM: UvrB/uvrC motif; UvrC Helix-hairpin-helix N-terminal; GIY-YIG catalytic domain; TIGRFAM: excinuclease ABC, C subunit; COGs: COG0322 Nuclease subunit of the excinuclease complex; HAMAP: UvrABC system protein C; InterProIPR004791:IPR000305:IPR001943:IPR001162:IPR 000445; KEGG: tgr:Tgr7_1907 excinuclease ABC subunit C; PFAM: Excinuclease ABC, C subunit, C-terminal; Excinuclease ABC, C subunit, N-terminal; UvrB/UvrC protein; Helix-hairpin-helix motif; SMART: Excinuclease ABC, C subunit, N-terminal; SPTR: UvrABC system protein C; TIGRFAM: Excinuclease ABC, [...]
  
   
 0.665
radA
DNA replication and repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
  
   
 0.662
EIJ35014.1
DNA replication and repair protein RecF; PFAM: RecF/RecN/SMC N terminal domain; TIGRFAM: recF protein; COGs: COG1195 Recombinational DNA repair ATPase (RecF pathway); HAMAP: DNA replication and repair protein recF; InterPro IPR003395:IPR001238; KEGG: ebi:EbC_45640 DNA replication and repair protein; PFAM: RecF/RecN/SMC protein, N-terminal; SPTR: DNA replication and repair protein recF; TIGRFAM: DNA-binding, RecF.
  
   
 0.656
EIJ34390.1
PFAM: Holliday junction DNA helicase ruvB C-terminus; Holliday junction DNA helicase ruvB N-terminus; TIGRFAM: Holliday junction DNA helicase, RuvB subunit; COGs: COG2255 Holliday junction resolvasome helicase subunit; HAMAP: DNA helicase, Holliday junction RuvB type; InterProIPR004605:IPR003593:IPR008824:IPR003959:IPR 008823; KEGG: hch:HCH_04922 Holliday junction DNA helicase RuvB; PFAM: DNA helicase, Holliday junction RuvB type, C-terminal; ATPase, AAA-type, core; DNA helicase, Holliday junction RuvB type, N-terminal; SMART: ATPase, AAA+ type, core; SPTR: Holliday junction ATP-depend [...]
 
  
 0.639
Your Current Organism:
Thiothrix nivea
NCBI taxonomy Id: 870187
Other names: T. nivea DSM 5205, Thiothrix nivea DSM 5205, Thiothrix nivea JP2, Thiothrix nivea str. DSM 5205, Thiothrix nivea strain DSM 5205
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