A0A0C3KPV1 protein (Pisolithus tinctorius) - STRING interaction network

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query proteins and first shell of interactors

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

A0A0C3KPV1

HMG box domain-containing protein. (467 aa)

Predicted Functional Partners:

A0A0C3PVV2

0.711

A0A0C3PJF6

0.702

A0A0C3KV93

0.654

A0A0C3P641

0.618

A0A0C3PFX0

0.618

A0A0C3PZ70

0.618

A0A0C3NV08

0.592

A0A0C3P098

0.592

A0A0C3MZ74

0.586

A0A0C3NUG3

0.577

Your Current Organism:

Pisolithus tinctorius

NCBI taxonomy Id: 870435
Other names: P. tinctorius Marx 270, Pisolithus tinctorius ATCC MYA-4688, Pisolithus tinctorius Marx 270

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A0C3KPV1	A0A0C3KV93	HMG box domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.654
A0A0C3KPV1	A0A0C3MZ74	HMG box domain-containing protein.	Uncharacterized protein.	0.586
A0A0C3KPV1	A0A0C3NUG3	HMG box domain-containing protein.	Uncharacterized protein.	0.577
A0A0C3KPV1	A0A0C3NV08	HMG box domain-containing protein.	Autophagy-related protein; Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation; Belongs to the ATG22 family.	0.592
A0A0C3KPV1	A0A0C3P098	HMG box domain-containing protein.	Autophagy-related protein; Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation; Belongs to the ATG22 family.	0.592
A0A0C3KPV1	A0A0C3P641	HMG box domain-containing protein.	Uncharacterized protein.	0.618
A0A0C3KPV1	A0A0C3PFX0	HMG box domain-containing protein.	Uncharacterized protein.	0.618
A0A0C3KPV1	A0A0C3PJF6	HMG box domain-containing protein.	HMG box domain-containing protein.	0.702
A0A0C3KPV1	A0A0C3PVV2	HMG box domain-containing protein.	Uncharacterized protein.	0.711
A0A0C3KPV1	A0A0C3PZ70	HMG box domain-containing protein.	Uridine kinase; Belongs to the uridine kinase family.	0.618
A0A0C3KV93	A0A0C3KPV1	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	HMG box domain-containing protein.	0.654
A0A0C3KV93	A0A0C3MZ74	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Uncharacterized protein.	0.653
A0A0C3MZ74	A0A0C3KPV1	Uncharacterized protein.	HMG box domain-containing protein.	0.586
A0A0C3MZ74	A0A0C3KV93	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.653
A0A0C3NUG3	A0A0C3KPV1	Uncharacterized protein.	HMG box domain-containing protein.	0.577
A0A0C3NUG3	A0A0C3PJF6	Uncharacterized protein.	HMG box domain-containing protein.	0.971
A0A0C3NV08	A0A0C3KPV1	Autophagy-related protein; Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation; Belongs to the ATG22 family.	HMG box domain-containing protein.	0.592
A0A0C3P098	A0A0C3KPV1	Autophagy-related protein; Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation; Belongs to the ATG22 family.	HMG box domain-containing protein.	0.592
A0A0C3P641	A0A0C3KPV1	Uncharacterized protein.	HMG box domain-containing protein.	0.618
A0A0C3P641	A0A0C3PFX0	Uncharacterized protein.	Uncharacterized protein.	0.960

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

17

average node degree:

3.09

avg. local clustering coefficient:

0.787

expected number of edges:

11

PPI enrichment p-value:

0.0608

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007507

Heart development

2 of 3

2.91

0.91

0.0226

GO:0000743

Nuclear migration involved in conjugation with cellular fusion

2 of 4

2.78

0.91

0.0226

GO:0000132

Establishment of mitotic spindle orientation

2 of 7

2.54

0.9

0.0226

GO:0000747

Conjugation with cellular fusion

3 of 41

1.95

0.87

0.0226

GO:0007017

Microtubule-based process

3 of 128

1.45

0.63

0.0491

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032977

Membrane insertase activity

3 of 10

2.56

1.96

0.00024

GO:0005200

Structural constituent of cytoskeleton

2 of 5

2.68

1.14

0.0086

GO:0051010

Microtubule plus-end binding

2 of 14

2.24

0.83

0.0295

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005875

Microtubule associated complex

7 of 32

2.42

6.04

3.21e-13

GO:0005869

Dynactin complex

5 of 7

2.94

5.54

4.90e-11

GO:0015629

Actin cytoskeleton

6 of 123

1.77

2.87

6.12e-08

GO:0072546

EMC complex

3 of 11

2.52

2.5

2.03e-05

GO:0005856

Cytoskeleton

8 of 367

1.42

2.2

1.76e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5936

Dynactin complex, and Dynein complex

8 of 13

2.87

9.05

3.39e-18

CL:5951

Dynactin complex, and Cell projection assembly

4 of 5

2.99

4.35

9.76e-09

CL:19836

EMC complex

3 of 10

2.56

2.41

3.26e-05

CL:5938

Dynein heavy chain binding, and Dynamitin

2 of 5

2.68

1.39

0.0029

CL:19838

EMC complex

2 of 5

2.68

1.39

0.0029

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6811436

COPI-independent Golgi-to-ER retrograde traffic

6 of 15

2.68

5.95

3.17e-12

MAP-2132295

MHC class II antigen presentation

6 of 46

2.2

4.39

3.93e-10

MAP-6807878

COPI-mediated anterograde transport

7 of 83

2.01

4.25

8.07e-11

MAP-3371497

HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand

6 of 52

2.14

4.23

5.84e-10

MAP-199977

ER to Golgi Anterograde Transport

7 of 141

1.78

3.35

1.14e-09

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005869

Dynactin complex

5 of 7

2.94

5.49

6.08e-11

GOCC:0005875

Microtubule associated complex

7 of 58

2.16

4.83

1.79e-11

GOCC:0015629

Actin cytoskeleton

6 of 113

1.81

2.98

4.65e-08

GOCC:0005856

Cytoskeleton

8 of 335

1.46

2.33

1.07e-08

GOCC:0072546

ER membrane protein complex

2 of 10

2.38

1.21

0.0059

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12455

Dynein associated protein

2 of 2

3.08

1.19

0.0071

PF00132

Bacterial transferase hexapeptide (six repeats)

2 of 5

2.68

1.05

0.0123

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR047125

Dynactin subunit 5

2 of 2

3.08

0.96

0.0186

IPR036859

CAP Gly-rich domain superfamily

2 of 4

2.78

0.96

0.0186

IPR022157

Dynein associated protein

2 of 2

3.08

0.96

0.0186

IPR000938

CAP Gly-rich domain

2 of 4

2.78

0.96

0.0186

IPR011004

Trimeric LpxA-like superfamily

2 of 8

2.48

0.85

0.0279

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01052

Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including ...

2 of 4

2.78

1.32

0.0040

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